Uniprot ID	P78032
Uniprot Name	TOP1_MYCPN
Taxonomy ID	272634
Sequence	M S K N L V V I E S P N K V K T L Q K Y L P N D F E I V S T I G H I R E M V H K N F G F N E A D Y S P V W E D W T K S K K K F S S L S F K G N L K G K K L L S K Y D I I K S I K E K A S K A T N I Y L A T D P D R E G E A I S W H V Y D V L D E K D K S K C Q R I T F N E I T K N A V L D A L K N P R E I D Q S W V Q S Q F A R Q I L D R M I G F R L S R L L N N Y L S A K S A G R V Q S V A L R F L E E R E Q E I R S F V P R F W W T L D V L L N P K A E G V R E A C A N R S I P I V L R E I N P A L R A G L K F E E E K S V S G I D F L D E A S A K K F G E Q L K G V F E V Y N I D E T K H Y S S S P N S A Y T T A S L Q K D A I N K L G W S S K K V T L I A Q H L Y E G V S I N G E Q T A L I S Y P R T D S T R L S A Q F Q Q S C K E Y I L N H Y G E K Y L S N R I V S A K G K K G E K I I Q D A H E A I H P T D I N I T P E M V K N A I K K D E F L L Y R L I W I R T V A S L M A D C K K S H T H I R F I N D G N K F Y A S S K S L V F D G Y R K I Y E H F E N K E S N D L Y I D L D K I R V G D R F M A K D I K I T A R Q T H P A A R Y T Q A S L I E A L E K S N I G R P S T Y N T M A S V N L D R G Y A S L N K H A F H V T Q L G E Q V N E E L S K H F G K I I N K E F T K N M E K S L D E I A E N K K N Y Q E F L R D F W S N F K E E V K L A E G S I Q R V K K E K E F V G R D C P S C A S P L L Y R Y T K R G N E K F V G C S N F P N C K Y N E F S Q N K P N L T L E K L E E L C P E C N S Q L V K R R T K F N P N K T F V G C S N F P R C R Y I K K D N A S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952};
Active site	ACT_SITE 340 340 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}.
Pfam	PF01131 PF01751 PF01396
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR013498 IPR005733 IPR028612 IPR006171 IPR034149