Uniprot ID	P87515
Uniprot Name	POLN_BFV
Taxonomy ID	11020
Sequence	M A K P V V K I D V E P E S H F A K Q V Q S C F P Q F E I E A V Q T T P N D H A H A R A F S H L A T K L I E M E T A K D Q I I L D I G S A P A R R L Y S E H K Y H C V C P M K C T E D P E R M L G Y A R K L I A G S A K G K A E K L R D L R D V L A T P D I E T Q S L C L H T D A S C R Y R G D V A V Y Q D V Y A I D A P T T L Y H Q A L K G V R T A Y W I G F D T T P F M Y D A L A G A Y P L Y S T N W A D E Q V L E S R N I G L C S D K V S E G G K K G R S I L R K K F L K Q S D R V M F S V G S T L Y T E S R K L L Q S W H L P S T F H L K G K S S F T C R C D T I V S C E G Y V L K K I T M C P G V T G K P I G Y A V T H H K E G F V V G K V T D T I R G E R V S F A V C T Y V P T T L C D Q M T G I L A T E V T A D D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P L V A Q A L A K W A K E A K Q D M E D E R P L N E R Q R T L T C L C C W A F K R N K R H A I Y K R P D T Q S I V K V P C E F T S F P L V S L W S A G M S I S L R Q K L K M M L Q A R Q P T Q I A A V T E E L I Q E A A A V E Q E A V D T A N A E L D H A A W P S I V D T T E R H V E V E V E E L D Q R A G E G V V E T P R N S I K V S T Q I G D A L I G S Y L I L S P Q A V L R S E K L A C I H D L A E Q V K L V T H S G R S G R Y A V D K Y X G R V L V P T G V A I D I Q S F Q A L S E S A T L V Y N E R E F V N R K L W H I A V Y G A A L N T D E E G Y E K V P V E R A E S D Y V F D V D Q K M C L K K E Q A S G W V L C G E L V N P P F H E F A Y E G L R T R P S A P Y K V H T V G V Y G V P G S G K S A I I K N T V T M S D L V L S G K K E N C L E I M N D V L K H R A L R I T A K T V D S V L L N G V K H T P N I L Y I D E A F S C H A G T L L A T I A I V R P K Q K V V L C G D P K Q C G F F N M M Q L K V N Y N H D I C S E V F H K S I S R R C T Q D I T A I V S K L H Y Q D R M R T T N P R K G D I I I D T T G T T K P A K T D L I L T C F R G W V K Q L Q Q D Y R G N E V M T A A A S Q G L T R A S V Y A V R T K V N E N P L Y A Q T S E H V N V L L T R T E N K L V W K T L S T D P W I K T L T N P P R G H Y T A T I A E W E A E H Q G I M K A I Q G Y A P P V N T F M N K V N V C W A K T L T P V L E T A G I S L S A E D W S E L L P P F A Q D V A Y S P E V A L N I I C T K M Y G F D L D T G L F S R P S V P M T Y T K D H W D N R V G G K M Y G F S Q Q A Y D Q L A R R H P Y L R G R E K S G M Q I V V T E M R I Q R P R S D A N I I P I N R R L P H S L V A T H E Y R R A A R A E E F F T T T R G Y T M L L V S E Y N M N L P N K K I T W L A P I G T Q G A H H T A N L N L G I P P L L G S F D A V V V N M P T P F R N H H Y Q Q C E D H A M K L Q M L A G D A L R H I K P G G S L W V K A Y G Y A D R H S E H V V L A L A R K F K S F R V T Q P S C V T S N T E V F L H F S I F D N G K R A I A L H S A N R K A N S I F Q N T F L P A G S A P A Y R V K R G D I S N A P E D A V V N A A N Q Q G V K G A G V C G A I Y R K W P D A F G D V A T P T G T A V S K S V Q D K L V I H A V G P N F S K C S E E E G D R D L A S A Y R A A A E I V M D K K I T T V A V P L L S T G I Y A G G K N R V E Q S L N H L F T A F D N T D A D V T I Y C M D K T W E K K I K E A I D H R T S V E M V Q D D V Q L E E E L V R V H P L S S L A G R K G Y S T D S G R V F S Y L E G T K F H Q T A V D I A E M Q V L W P A L K E S N E Q I V A Y T L G E S M D Q I R G K C P T E D T D A S T P P R T V P C L C R Y A M T P E R V Y R L K C T N T T Q F T V C S S F E L P K Y H I Q G V Q R V K C E R I I I L D P T V P P T Y K R P C I R R Y P S T I S C N S S E D S R S L S T F S V S S D S S I G S L P V G D T R P I P A P R T I F R P V P A P R A P V L R T T P P P K P P R T F T V R A E V H Q A P P T P V P P P R P K R A A K L A R E M H P G F T F G D F G E H E V E E L T A S P L T F G D F A E G E I Q G M G V E F E X L G R A G G Y I F S S D T G P G H L Q Q R S V L Q N C T A E C I Y E P A K L E K I H A P K L D K T K E D I L R S K Y Q M K P S E A N K S R Y Q S R K V E N M K A E I V G R L L D G L G E Y L G T E H P V E C Y R I T Y P V P I Y S T S D L R G L S S A K T A V R A C N A F L E A N F P S V T S Y K I T D E Y D A Y L D M V D G S E S C L D R S S F S P S R L R S F P K T H S Y L D P Q I N S A V P S P F Q N T L Q N V L A A A T K R N C N V T Q M R E L P T Y D S A V L N V E A F R K Y A C K P D V W D E Y R D N P I C I T T E N V T T Y V A K L K G P K A A A L F A K T H N L I P L H Q V P M D K F T V D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L N N A L F P N I H T L F D M S A E D F D A I I A E H F K H G D H V L E T D I A S F D K S Q D D S M A L T A L M I L E D L G V D Q N L M N L I E A A F G E I V S T H L P T G T R F K F G A M M K S G M F L T L F V N T I L N V V I A C R V L E D Q L A Q S P W P A F I G D D N I I H G I I S D K L M A D R C A T W M N M E V K I L D S I V G I R P P Y F C G G F I V C D D V T G T A C R V A D P L K R L F K L G K P L P L D D G Q D E D R R R A L H D E V K T W S R V G L R H R V C E A I E D R Y A V H S S E L V L L A L T T L S K N L K S F R N I R G K P I H L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1011 1011 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1081 1081 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR029063 IPR001788