Uniprot ID	P90520
Uniprot Name	TOP2M_DICDI
Taxonomy ID	44689
Sequence	M S K L L N N N N H K N L T N Y L K F G K G I I N N L N N K S K Q V G I I S F I S Q S S I Q S Q S S I Q S Q S F L S I N N N S N N K Y F S T K L N K N E K I S E K T T T R K I E D I Y Q K K T P T E H V L L R P D S Y I G T I E K I E D D M W V L S N S M F N K E K K T I E L N N D N N E K N V E S T T T T T T K T N K K P L T Y I H P I K A T Y I P G L L K I Y D E I L V N A A D N K K R D S K M S F I K V E I N P N E N S I S I M N D G K G I P V V M H Q T E N C Y V V E M V M G N L M S G S N F N D S E L K V V G G R N G F G A K L T N I F S K E F T V E T V D K S S G K K Y F Q R W S N N M G D R S E P I I T P I G E G E S D Y T K I T F K P D L E K F K I K S L W D D N I L Q L M E R R L Y D I A G C N T E L M V T L N G K R L N Y N F Q S Y V K L Y E H H L N N S T K R E D N E E Q Y R E E S F E F G E I S P R W K I G I G L S E T G Q F T Q V S F V N S I N T V K G G T H V N F L A D Q I V R Y V G E K L K K K H S D L E I R P M N I K H H L A L F V N C L V D N P S F D S Q S K E T L T T K P M L F G S T P E I P E S L L A Q F V K N S K I I E R V A G W A L M K Q K A D L I H S T S G R Q S K T T L I K S I S K L D D A N W A G G L K S K E C T L I I T E G D S A K S L A L A G L S V V G R N S Y G V F P L R G K L L N V R D V A S K Q L L S N E E I N N L T T I L G L S H K N S Y D T D E S M E D L R Y G R V M I M A D Q D H D G S H I K G L V M N F I H Y F W P N L L K R G F L V E F V T P I I K A T K S S T Q K K S F F T I K D Y E K W R E T I S S D Q L K Q Y T I K Y Y K G L G T S T S A E A K E Y F S N L D K H V I K F I W G D E A D D L I K M A F A K D L S S L R Q R W I K E T D M S Q G I D H S I K E I T Y P D F I N K E L I H Y S W A A N L R S I P S L I D G L K P G Q R K I L F A S F K R R L T N E I K V S Q L S G Y V A E Q T S Y H H G E Q S L N S T I V K M A H N F V G S N N L P L L T P S G Q F G T R L Q G G S D S A S A R Y I F T K L E P V A R Y L F N E L D D P L L N Y L E E E G E S I Q P D Y Y I P I I P M L L V N G S E G I G V G M S T S I P L F S P I D I I D Q L M L R L N N Q V A L K K L I P W Y R G F K G T I S P D R H T Y R T N G V I K L V G R N L E I T E L P I G R W T S D Y K E V L N D L I D K D V I K S F Q E S N T E N S V H F T I L L N N N Q L E Q M E D L T E N E L I K L F K L S A S L N F H L T C F D E N S K I Q K L E S V E E I I D Q F Y K V R L Q F Y G K R R E Y L L K S L D N Q I K R L T T T I Q F L E V I A S G K L K I Q G R S K Q D L I K E L E S G E I V G F E N F G T H P P E V Y Q H L F S L S I L D I T K E R I D N L T N Q L T K R K S E H Q S I S S S D P K S L W T A D L Q Q L K E Y L E K S D K E F Q K K P L K T S S S S S F D V S S S S E S A K L S S T R K S K T D K I K S K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 900 900 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157