Uniprot ID	P9WGK1
Uniprot Name	DOST_MYCTU
Taxonomy ID	83332
Sequence	M T H P D R A N V N P G S P P L R E T L S Q L R L R E L L L E V Q D R I E Q I V E G R D R L D G L I D A I L A I T S G L K L D A T L R A I V H T A A E L V D A R Y G A L G V R G Y D H R L V E F V Y E G I D E E T R H L I G S L P E G R G V L G A L I E E P K P I R L D D I S R H P A S V G F P L H H P P M R T F L G V P V R I R D E V F G N L Y L T E K A D G Q P F S D D D E V L V Q A L A A A A G I A V D N A R L F E E S R T R E A W I E A T R D I G T Q M L A G A D P A M V F R L I A E E A L T L M A G A A T L V A V P L D D E A P A C E V D D L V I V E V A G E I S P A V K Q M T V A V S G T S I G G V F H D R T P R R F D R L D L A V D G P V E P G P A L V L P L R A A D T V A G V L V A L R S A D E Q P F S D K Q L D M M A A F A D Q A A L A W R L A T A Q R Q M R E V E I L T D R D R I A R D L H D H V I Q R L F A V G L T L Q G A A P R A R V P A V R E S I Y S S I D D L Q E I I Q E I R S A I F D L H A G P S R A T G L R H R L D K V I D Q L A I P A L H T T V Q Y T G P L S V V D T V L A N H A E A V L R E A V S N A V R H A N A T S L A I N V S V E D D V R V E V V D D G V G I S G D I T E S G L R N L R Q R A D D A G G E F T V E N M P T G G T L L R W S A P L R
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15135056, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:28977726}; Note=Mg(2+). Both Mn(2+) and Ca(2+) can substitute Mg(2+) ion in the autophosphorylation reaction but not for phosphate transfer to DevR (DosR) (PubMed:15135056). In another study Mn(2+) and Ca(2+) substitute poorly for autophosphorylation (PubMed:17600145). In another study Mg(2+) or Mn(2+) are required for transfer, but Ca(2+) does not substitute as well (PubMed:28977726). {ECO:0000269|PubMed:15135056, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:28977726}; COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:15135056, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:18980385}; Note=Binds 1 heme group per monomer (PubMed:15135056, PubMed:17600145, PubMed:18980385). Half-life of Fe(2+) DosT is over 60 hours in air (PubMed:17600145). {ECO:0000269|PubMed:15135056, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:18980385};
Active site	No current data
Pfam	PF13185 PF13492 PF02518 PF07730
InterPro	IPR003018 IPR029016 IPR003594 IPR036890 IPR011712