Uniprot ID	Q01879
Uniprot Name	TOP2_PICGU
Taxonomy ID	294746
Sequence	M S S F E S D S A S D A E S A F S D A S S D F T P S S S V K S K G K V P L R D S T N T T A Q P S A P A T G D A S D Q Y Q K L S Q L E H I L K R P D T Y I G S V E K T G V E M W S F D A A T E S M I Y K E V H I V P G L Y K I F D E I L V N A A D N K I R D P S M R N I K V N I D A E N N T I S V M N D G K G I P I E I H K K E K I Y I P E L I F G N L L T S S N Y D D D E K K V T G G R N G Y G A K L C N I F S T E F V L E T A D L N T S Q V Y K Q T W T N N M A N L T K P K I T K L K S K K E Y T K V T F K P D L S K F H M E M L D D D I L S V L R R R V Y D L C G T V K D C N I Y L N D K K L S I R N F K S Y V E M Y V N A I R E R S P D P V A P E G E T R N Y S T I V H E V F N D R W E V A F A V S D G S F N Q V S F V N S I A T T S G G T H V K Y V S D Q I I T K L I D A L T K K E K G K K K L N I K P Q E V R N N M F V F I N C L I E N P A F T S Q T K E Q L T T R V A Q F G G K P S E K I V I S D Q F I A K I L K T S I A D K I R T I V N A N E D K E M S K A D G S R K S R I K N Q V K L V D A N K A G T K E G Y K C T L I L T E G D S A M P L A V A G L T V V G R D Y Y G C F P L R G K L L N V R E A S I E Q V S K N A E I N S I K Q I M G L Q H K K R Y T P E N I K S L R Y G H I M I M T D Q D Q D G S H I K G L I I N F L E T S F P G L L E I P G F L L E F I T P I V K V T I T G R G N H R V I P F Y N M P E F E K W R E T E G T T C K W K H K Y F K G L G T S L E S E G R E Y F A A L D R H M K S F H A L Q D G D S Q Y I D M A F S K K K A D E R K D W L Q A F R P G T H L D P Q I R E I P I S E F I N K E L I L F S M A D N V R S I P S I L D G F K P G Q R K V L Y G C F K R N L R S E I K V A Q L V G Y I S E H T G Y H H G E G S L A Q T I V G L A Q N F V G A N N L N L L Q P I G L F G S R A A G G K D F S A V R Y I H T N I T D L T R V I F N P L D D D L Y T Y V Q D D A Q T V E P E A Y L P I I P M L L V N G A E G I G T G W S T N I P S F N P V D I V A N I R R M M N G E E P V D M T P W F K G W E G D L E R I S P E K Y K V S G K I E Q V D D D T V E I T E I P I K T W T N S V K E F L L A G L G N D K P W I K D M E E Q H G I N I R F V V R L S K E E M D K S L R M G L L E R F K L I S S I S L S N M V A F D P Q G R I K K Y S S A N E I L K D Y Y W A R L E L Y Q R R K D M M A E N F Q N Q L T R L S E Q A R F I K L I I E K K L T I A N K K R S E M V D D L K K L K F T R F N K N G K P V H D E P L V E A E E L A E E E E E A A G D I S Q L N L G L V A P E D E S Q Y K P E T T Y S Q Y D Y L L G M A I W S L T R E R Y E K L L R Q R D E K Q E E L N E L L K K S A K D L W N S D L D D F L V G W E E F L R A D I E A R N S F G P T A K T S T R K R A R K S T K S E P A Q K K T K S S T P K A S T P T I K A E A T P A Q P V V K E E T N K Q P D L L S F F S K E P S V A K T V S A A P P K R K T P K S K P K K E I V S L F S D S S D D D I T S F S V G D A K P T P K P S T N N I L D E L E D L K S S T F T P K V G A A G R R R P K S Y A L A E S D G N E S D E D Y M S E
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 839 839 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR031660 IPR006171 IPR034157