Uniprot ID	Q04561
Uniprot Name	RPOA_PRRSL
Taxonomy ID	11049
Sequence	M S G T F S R C M C T P A A R V F W N A G Q V F C T R C L S A R S L L S P E L Q D T D L G A V G L F Y K P R D K L H W K V P I G I P Q V E C T P S G C C W L S A V F P L A R M T S G N H N F L Q R L V K V A D V L Y R D G C L A P R H L R E L Q V Y E R G C N W Y P I T G P V P G M G L F A N S M H V S D Q P F P G A T H V L T N S P L P Q Q A C R Q P F C P F E E A H S S V Y R W K K F V V F T D S S L N G R S R M M W T P E S D D S A A L E V L P P E L E R Q V E I L I R S F P A H H P V D L A D W E L T E S P E N G F S F N T S H S C G H L V Q N P D V F D G K C W L S C F L G Q S V E V R C H E E H L A D A F G Y Q T K W G V H G K Y L Q R R L Q V R G I R A V V D P D G P I H V E A L S C P Q S W I R H L T L D D D V T P G F V R L T S L R I V P N T E P T T S R I F R F G A H K W Y G A A G K R A R A K R A A K S E K D S A P T P K V A L P V P T C G I T T Y S P P T D G S C G W H V L A A I M N R M I N G D F T S P L T Q Y N R P E D D W A S D Y D L V Q A I Q C L R L P A T V V R N R A C P N A K Y L I K L N G V H W E V E V R S G M A P R S L S R E C V V G V C S E G C V A P P Y P A D G L P K R A L E A L A S A Y R L P S D C V S S G I A D F L A N P P P Q E F W T L D K M L T S P S P E R S G F S S L Y K L L L E V V P Q K C G A T E G A F I Y A V E R M L K D C P S S K Q A M A L L A K I K V P S S K A P S V S L D E C F P T D V L A D F E P A S Q E R P Q S S G A A V V L C S P D A K E F E E A A P E E V Q E S G H K A V H S A L L A E G P N N E Q V Q V V A G E Q L K L G G C G L A V G N A H E G A L V S A G L I N L V G G N L S P S D P M K E N M L N S R E D E P L D L S Q P A P A S T T T L V R E Q T P D N P G S D A G A L P V T V R E F V P T G P I L C H V E H C G T E S G D S S S P L D L S D A Q T L D Q P L N L S L A A W P V R A T A S D P G W V H G R R E P V F V K P R N A F S D G D S A L Q F G E L S E S S S V I E F D R T K D A P V V D A P V D L T T S N E A L S V V D P F E F A E L K R P R F S A Q A L I D R G G P L A D V H A K I K N R V Y E Q C L Q A C E P G S R A T P A T R E W L D K M W D R V D M K T W R C T S Q F Q A G R I L A S L K F L P D M I Q D T P P P V P R K N R A S D N A G L K Q L V A Q W D R K L S V T P P P K P V G P V L D Q I V P P P T D I Q Q E D V T P S D G P P H A P D F P S R V S T G G S W K G L M L S G T R L A G S I S Q R L M T W V F E V F S H L P A F M L T L F S P R G S M A P G D W L F A G V V L L A L L L C R S Y P I L G C L P L L G V F S G S L R R V R L G V F G S W M A F A V F L F S T P S N P V G S S C D H D S P E C H A E L L A L E Q R Q L W E P V R G L V V G P S G L L C V I L G K L L G G S R Y L W H V L L R L C M L A D L A L S L V Y V V S Q G R C H K C W G K C I R T A P A E V A L N V F P F S R A T R V S L V S L C D R F Q T P K G V D P V H L A T G W R G C W R G E S P I H Q P H Q K P I A Y A N L D E K K M S A Q T V V A V P Y D P S Q A I K C L K V L Q A G G A I V D Q P T P E V V R V S E I P F S A P F F P K V P V N P D C R V V V D S D T F V A A V R C G Y S T A Q L V L G R G N F A K L N Q T P P R N S I S T K T T G G A S Y T L A V A Q V S A W T L V H F I L G L W F T S P Q V C G R G T A D P W C S N P F S Y P T Y G P G V V C S S R L C V S A D G V T L P L F S A V A Q L S G R E V G I F I L V L V S L T A L A H R M A L K A D M L V V F S A F C A Y A W P M S S W L I C F F P I L L K W V T L H P L T M L W V H S F L V F C L P A A G I L S L G I T G L L W A I G R F T Q V A G I I T P Y D I H Q Y T S G P R G A A A V A T A P E G T Y M A A V R R A A L T G R T L I F T P S A V G S L L E G A F R T H K P C L N T V N V V G S S L G S G G V F T I D G R R T V V T A A H V L N G D T A R V T G D S Y N R M H T F K T N G D Y A W S H A D D W Q G V A P V V K V A K G Y R G R A Y W Q T S T G V E P G I I G E G F A F C F T N C G D S G S P V I S E S G D L I G I H T G S N K L G S G L V T T P E G E T C T I K E T K L S D L S R H F A G P S V P L G D I K L S P A I I P D V T S I P S D L A S L L A S V P V V E G G L S T V Q L L C V F F L L W R M M G H A W T P I V A V G F F L L N E I L P A V L V R A V F S F A L F V L A W A T P W S A Q V L M I R L L T A S L N R N K L S L A F Y A L G G V V G L A A E I G T F A G R L S E L S Q A L S T Y C F L P R V L A M T S C V P T I I I G G L H T L G V I L W L F K Y R C L H N M L V G D G S F S S A F F L R Y F A E G N L R K G V S Q S C G M N N E S L T A A L A C K L S Q A D L D F L S S L T N F K C F V S A S N M K N A A G Q Y I E A A Y A K A L R Q E L A S L V Q I D K M K G V L S K L E A F A E T A T P S L D I G D V I V L L G Q H P H G S I L D I N V G T E R K T V S V Q E T R S L G G S K F S V C T V V S N T P V D A L T G I P L Q T P T P L F E N G P R H R S E E D D L K V E R M K K H C V S L G F H N I N G K V Y C K I W D K S T G D T F Y T D D S R Y T Q D H A F Q D R S A D Y R D R D Y E G V Q T T P Q Q G F D P K S E T P V G T V V I G G I T Y N R Y L I K G K E V L V P K P D N C L E A A K L S L E Q A L A G M G Q T C D L T A A E V E K L K R I I S Q L Q G L T T E Q A L N C L L A A S G L T R C G R G G L V V T E T A V K I I K Y H S R T F T L G P L D L K V T S E V E V K K S T E Q G H A V V A N L C S G V I L M R P H P P S L V D V L L K P G L D T I P G I Q P G H G A G N M G V D G S I W D F E T A P T K A E L E L S K Q I I Q A C E V R R G D A P N L Q L P Y K L Y P V R G D P E R H K G R L I N T R F G D L P Y K T P Q D T K S A I H A A C C L H P N G A P V S D G K S T L G T T L Q H G F E L Y V P T V P Y S V M E Y L D S R P D T P F M C T K H G T S K A A A E D L Q K Y D L S T Q G F V L P G V L R L V R R F I F G H I G K A P P L F L P S T Y P A K N S M A G I N G Q R F P T K D V Q S I P E I D E M C A R A V K E N W Q T V T P C T L K K Q Y C S K P K T R T I L G T N N F I A L A H R S A L S G V T Q A F M K K A W K S P I A L G K N K F K E L H C T V A G R C L E A D L A S C D R S T P A I V R W F V A N L L Y E L A G C E E Y L P S Y V L N C C H D L V A T Q D G A F T K R G G L S S G D P V T S V S N T V Y S L V I Y A Q H M V L S A L K M G H E I G L K F L E E Q L K F E D L L E I Q P M L V Y S D D L V L Y A E R P T F P N Y H W W V E H L D L M L G F R T D P K K T V I T D K P S F L G C R I E A G R Q L V P N R D R I L A A L A Y H M K A Q N A S E Y Y A S A A A I L M D S C A C I D H D P E W Y E D L I C G I A R C A R Q D G Y S F P G P A F F M S M W E K L R S H N E G K K F R H C G I C D A K A D Y A S A C G L D L C L F H S H F H Q H C P V T L S C G H H A G S K E C S Q C Q S P V G A G R S P L D A V L K Q I P Y K P P R T V I M K V G N K T T A L D P G R Y Q S R R G L V A V K R G I A G N E V D L S D G D Y Q V V P L L P T C K D I N M V K V A C N V L L S K F I V G P P G S G K T T W L L S Q V Q D D D V I Y T P T H Q T M F D I V S A L K V C R Y S I P G A S G L P F P P P A R S G P W V R L I A S G H V P G R V S Y L D E A G Y C N H L D I L R L L S K T P L V C L G D L Q Q L H P V G F D S Y C Y V F D Q M P Q K Q L T T I Y R F G P N I C A A I Q P C Y R E K L E S K A R N T R V V F T T R P V A F G Q V L T P Y H K D R I G S A I T I D S S Q G A T F D I V T L H L P S P K S L N K S R A L V A I T R A R H G L F I Y D P H N Q L Q E F F N L T P E R T D C N L V F S R G D E L V V L N A D N A V T T V A K A L E T G P S R F R V S D P R C K S L L A A C S A S L E G S C M P L P Q V A H N L G F Y F S P D S P T F A P L P K E L A P H W P V V T H Q N N R A W P D R L V A S M R P I D A R Y S K P M V G A G Y V V G P S T F L G T P G V V S Y Y L T L Y I R G E P Q A L P E T L V S T G R I A T D C R E Y L D A A E E E A A K E L P H A F I G D V K G T T V G G C H H I T S K Y L P R S L P K D S V A V V G V S S P G R A A K A V C T L T D V Y L P E L R P Y L Q P E T A S K C W K L K L D F R D V R L M V W K G A T A Y F Q L E G L T W S A L P D Y A R F I Q L P K D A V V Y I D P C I G P A T A N R K V V R T T D W R A D L A V T P Y D Y G A Q N I L T T A W F E D L G P Q W K I L G L Q P F R R A F G F E N T E D W A I L A R R M N D G K D Y T D Y N W N C V R E R P H A I Y G R A R D H T Y H F A P G T E L Q V E L G K P R L P P G Q V P
Cofactor	No current data
Active site	ACT_SITE 76 76 For nsp1-alpha papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00872, ECO:0000269|PubMed:7769711}.; ACT_SITE 146 146 For nsp1-alpha papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00872, ECO:0000269|PubMed:7769711}.; ACT_SITE 276 276 For nsp1-beta papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00873, ECO:0000269|PubMed:7769711}.; ACT_SITE 345 345 For nsp1-beta papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00873, ECO:0000269|PubMed:7769711}.; ACT_SITE 429 429 For nsp2 cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00871}.; ACT_SITE 498 498 For nsp2 cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00871}.; ACT_SITE 1732 1732 Charge relay system; for serine protease nsp4 activity. {ECO:0000255|PROSITE-ProRule:PRU00826, ECO:0000269|PubMed:19646449, ECO:0000269|PubMed:25008936}.; ACT_SITE 1757 1757 Charge relay system; for serine protease nsp4 activity. {ECO:0000255|PROSITE-ProRule:PRU00826, ECO:0000269|PubMed:19646449, ECO:0000269|PubMed:25008936}.; ACT_SITE 1810 1810 Charge relay system; for serine protease nsp4 activity. {ECO:0000255|PROSITE-ProRule:PRU00826, ECO:0000269|PubMed:19646449, ECO:0000269|PubMed:25008936}.
Pfam	PF16749 PF14757 PF14758 PF05410 PF05411 PF05412 PF05579 PF00680 PF01443
InterPro	IPR027351 IPR031932 IPR038451 IPR008743 IPR023338 IPR008741 IPR038155 IPR025773 IPR038154 IPR027355 IPR023183 IPR008760 IPR037227 IPR032855 IPR032841 IPR027417 IPR009003 IPR001205 IPR007094