Uniprot ID	Q07343
Uniprot Name	PDE4B_HUMAN
Taxonomy ID	9606
Sequence	M K K S R S V M T V M A D D N V K D Y F E C S L S K S Y S S S S N T L G I D L W R G R R C C S G N L Q L P P L S Q R Q S E R A R T P E G D G I S R P T T L P L T T L P S I A I T T V S Q E C F D V E N G P S P G R S P L D P Q A S S S A G L V L H A T F P G H S Q R R E S F L Y R S D S D Y D L S P K A M S R N S S L P S E Q H G D D L I V T P F A Q V L A S L R S V R N N F T I L T N L H G T S N K R S P A A S Q P P V S R V N P Q E E S Y Q K L A M E T L E E L D W C L D Q L E T I Q T Y R S V S E M A S N K F K R M L N R E L T H L S E M S R S G N Q V S E Y I S N T F L D K Q N D V E I P S P T Q K D R E K K K K Q Q L M T Q I S G V K K L M H S S S L N N T S I S R F G V N T E N E D H L A K E L E D L N K W G L N I F N V A G Y S H N R P L T C I M Y A I F Q E R D L L K T F R I S S D T F I T Y M M T L E D H Y H S D V A Y H N S L H A A D V A Q S T H V L L S T P A L D A V F T D L E I L A A I F A A A I H D V D H P G V S N Q F L I N T N S E L A L M Y N D E S V L E N H H L A V G F K L L Q E E H C D I F M N L T K K Q R Q T L R K M V I D M V L A T D M S K H M S L L A D L K T M V E T K K V T S S G V L L L D N Y T D R I Q V L R N M V H C A D L S N P T K S L E L Y R Q W T D R I M E E F F Q Q G D K E R E R G M E I S P M C D K H T A S V E K S Q V G F I D Y I V H P L W E T W A D L V Q P D A Q D I L D T L E D N R N W Y Q S M I P Q S P S P P L D E Q N R D C Q G L M E K F Q F E L T L D E E D S E G P E K E G E G H S Y F S S T K T L C V I D P E N R D S L G E T D I D I A T E D K S P V D T
Cofactor	COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452};
Active site	ACT_SITE 406 406 Proton donor.
Pfam	PF18100 PF00233
InterPro	IPR003607 IPR040844 IPR023088 IPR002073 IPR036971 IPR023174