Uniprot ID	Q14191
Uniprot Name	WRN_HUMAN
Taxonomy ID	9606
Sequence	M S E K K L E T T A Q Q R K C P E W M N V Q N K R C A V E E R K A C V R K S V F E D D L P F L E F T G S I V Y S Y D A S D C S F L S E D I S M S L S D G D V V G F D M E W P P L Y N R G K L G K V A L I Q L C V S E S K C Y L F H V S S M S V F P Q G L K M L L E N K A V K K A G V G I E G D Q W K L L R D F D I K L K N F V E L T D V A N K K L K C T E T W S L N S L V K H L L G K Q L L K D K S I R C S N W S K F P L T E D Q K L Y A A T D A Y A G F I I Y R N L E I L D D T V Q R F A I N K E E E I L L S D M N K Q L T S I S E E V M D L A K H L P H A F S K L E N P R R V S I L L K D I S E N L Y S L R R M I I G S T N I E T E L R P S N N L N L L S F E D S T T G G V Q Q K Q I R E H E V L I H V E D E T W D P T L D H L A K H D G E D V L G N K V E R K E D G F E D G V E D N K L K E N M E R A C L M S L D I T E H E L Q I L E Q Q S Q E E Y L S D I A Y K S T E H L S P N D N E N D T S Y V I E S D E D L E M E M L K H L S P N D N E N D T S Y V I E S D E D L E M E M L K S L E N L N S G T V E P T H S K C L K M E R N L G L P T K E E E E D D E N E A N E G E E D D D K D F L W P A P N E E Q V T C L K M Y F G H S S F K P V Q W K V I H S V L E E R R D N V A V M A T G Y G K S L C F Q Y P P V Y V G K I G L V I S P L I S L M E D Q V L Q L K M S N I P A C F L G S A Q S E N V L T D I K L G K Y R I V Y V T P E Y C S G N M G L L Q Q L E A D I G I T L I A V D E A H C I S E W G H D F R D S F R K L G S L K T A L P M V P I V A L T A T A S S S I R E D I V R C L N L R N P Q I T C T G F D R P N L Y L E V R R K T G N I L Q D L Q P F L V K T S S H W E F E G P T I I Y C P S R K M T Q Q V T G E L R K L N L S C G T Y H A G M S F S T R K D I H H R F V R D E I Q C V I A T I A F G M G I N K A D I R Q V I H Y G A P K D M E S Y Y Q E I G R A G R D G L Q S S C H V L W A P A D I N L N R H L L T E I R N E K F R L Y K L K M M A K M E K Y L H S S R C R R Q I I L S H F E D K Q V Q K A S L G I M G T E K C C D N C R S R L D H C Y S M D D S E D T S W D F G P Q A F K L L S A V D I L G E K F G I G L P I L F L R G S N S Q R L A D Q Y R R H S L F G T G K D Q T E S W W K A F S R Q L I T E G F L V E V S R Y N K F M K I C A L T K K G R N W L H K A N T E S Q S L I L Q A N E E L C P K K L L L P S S K T V S S G T K E H C Y N Q V P V E L S T E K K S N L E K L Y S Y K P C D K I S S G S N I S K K S I M V Q S P E K A Y S S S Q P V I S A Q E Q E T Q I V L Y G K L V E A R Q K H A N K M D V P P A I L A T N K I L V D M A K M R P T T V E N V K R I D G V S E G K A A M L A P L L E V I K H F C Q T N S V Q T D L F S S T K P Q E E Q K T S L V A K N K I C T L S Q S M A I T Y S L F Q E K K M P L K S I A E S R I L P L M T I G M H L S Q A V K A G C P L D L E R A G L T P E V Q K I I A D V I R N P P V N S D M S K I S L I R M L V P E N I D T Y L I H M A I E I L K H G P D S G L Q P S C D V N K R R C F P G S E E I C S S S K R S K E E V G I N T E T S S A E R K R R L P V W F A K G S D T S K K L M D K T K R G G L F S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:16622405}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:16622405}; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:16622405}; Note=Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro). {ECO:0000269|PubMed:16622405};
Active site	No current data
Pfam	PF00270 PF01612 PF00271 PF00570 PF14493 PF16124 PF09382
InterPro	IPR002562 IPR011545 IPR004589 IPR014001 IPR001650 IPR029491 IPR010997 IPR002121 IPR027417 IPR032284 IPR012337 IPR036397 IPR018982 IPR036388 IPR036390