Uniprot ID	Q196X4
Uniprot Name	TOP2_IIV3
Taxonomy ID	345201
Sequence	M A P K N H Q K Y T I K N D I Q H V L D C S D V Y I G D T A P T A R S E W M F D D A V N Q I V W R P T T T P E A L V R I F V E V L T N A V D N I E R S I N G G H E L C K N I K V D V D L K T G K T S V W N D G Q V I P V V K N C D N G V V Q P P P P T T E Q D R L A Y E K L N R E Y I H T I I F G H F R T S S N Y D N E T D Q V S G K N G V G V K C T N I F S S W F S V V G V D P D R K L K F S Q E W R S N M T K S G A P Q V V K C A L K T G Y T L V E Y V P D F A R F K L K S Y P E D V E S I F K K L V V D A S A F F P N T A F F F N G E R T V V K N A V A Y A K L Y Y N L N E T A V D S V V I D Y K D S K V V V V G S A T P L P P V S F V N G Q I T P A G G Q H V T N W S R V I F G A L L A A L N G K K N V S L T K A D I A P Y F Q L F I H S K V S K P K F D G Q N K N C L K S P K V E A H L D A T I L K K M L K W K I I S T I Q D K V V K S K E Y L A L K K I E C R R T P I V K V D G Y D Q A N R L G P D S V L I V C E G L S A K S Y A V A G I Q K G L F N K K G R T Y F G I L P L R G K F L N V K N T T P L K I G Q N K V V S D F I K V L N L K F N L D Y R K A T N Y A T L N Y G T L L I L T D A D K D G I H I K G L I L N L I H E L F P T L F H R Q G F I Y S M E T P I V K I L H K K G Q P T L F Y D E N S F E D W R A Q H P E L K H F K Y Y K G L G T I G P A D V A A F F G S K V V R Y H Y D E A T D A A V N S V F K D E N A N E R K E W L G R F N P R V S Q W C L D H H R E A V I D L K I S D F M H H E M I K F S Y E D C R R S L A S C I D G F K E S Q R K I I Y A V R K K F R S N S T E F I K V A Q L S G Y V A E Q T D Y K H G E Q N L C E T I V K F A Q D F V G A N N V Q L L E P D G Q F G T R L E G G K D S A A P R Y I Y T K P H K I L P Y I F R E E D D P I L E Q S S E G E P V H F V P I I P L V L V N G S V G I G T G W S C F V P Q Y N P L E L I R Y I E A R L T S Q D S E A L L P A K P W Y R N F T G K V A A T G P G K F T T F G R M K Q V D A D T V R V T E L P V G M W T D R F K D Q C Y S L I E S G Q L Q Q L V N E S T V S K V D F T L K K L Q D I S A L K L T T T L H T T N M V L F D R E N V I T K Y D T I G D I L D H Y F Q T R L A F Y K V R K N H T I A Q L K N T I Q H N E T K L K F I E K V L T D H S F L R Q D D A A I V S I L E K E N F L K V D N S Y N Y L L N I S I R S C T A T A V E K L Q S T I K G L T E S L I R V Q Q T P T R Q M W Y D E L Q Q L K Q V G N W S E P
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 789 789 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250}.
Pfam	PF00204 PF00521 PF01751 PF16898
InterPro	IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR031660 IPR006171