Uniprot ID	Q23670
Uniprot Name	TOP2_CAEEL
Taxonomy ID	6239
Sequence	M S D S D S E F S I E D S P K K K T A P K K E K A S P K K K K D D A N E S M V M T E E D R N V F T S I D K K G G G S K Q M A I E D I Y Q K K S Q L E H I L L R P D T Y I G S V E H T E K T P M W V Y N M E E S K L E Q R D I S Y V P G L Y K I Y D E I L V N A A D N K Q R D P K M N T I K I T I N K E K N E I S V Y N N G K G I P V T Q H K V E K V Y V P E L I F G T L L T S S N Y N D D E K K V T G G R N G Y G A K L C N I F S T K F T L E T S S R D Y K S A F K Q T W I K N M T R D E E P K I V K S T D E D F T K I T F S P D L A K F K M K E L D D D I C H L M A R R A Y D V A G S S K G V A V F L N G K R I P I K G F E D Y V Q M Y T S Q F N N E G E P L K I A Y E Q V G D R W Q V A L A L S E K G F Q Q V S F V N S I A T T K G G R H V D Y V A D Q M V A K F I D S I K R K L T K T S M N I K P F Q I K N H M W V F V N C L I E N P T F D S Q T K E T M T L Q Q K Q F G S T C V L S E K F S K A A S S V G I T D A V M S W V R F K Q M D D L N K K C S K T K T S K L K G I P K L E D A N D A G T K N S Q Q C T L I L T E G D S A K T L A V S G L S V V G R D K Y G V F P L R G K L L N V R E G N M K Q I A D N A E V N A M I K I L G L Q Y K K K Y E T E D D F K T L R Y G K L M V M A D Q D Q D G S H I K G L V I N F I H H F W P S L I Q R N F V E E F I T P I V K A T K G K E E V S F Y S L P E Y S E W R M N T D N W K S Y K I K Y Y K G L G T S T S K E A K E Y F L D M V R H R I R F K Y N G A D D D N A V D M A F S K K K I E E R K D W L S K W M R E K K D R K Q Q G L A E E Y L Y N K D T R F V T F K D F V N R E L V L F S N L D N E R S I P C L V D G F K P G Q R K V L F A C F K R A D K R E V K V A Q L A G A V A E I S A Y H H G E Q S L M G T I V N L A Q D Y V G S N N I N L L L P I G Q F G T R L Q G G K D S A S A R Y I F T Q L S P V T R T L F P A H D D N V L R F L Y E E N Q R I E P E W Y C P I I P M V L V N G A Q G I G T G W S T N I P N Y N P R E L V K N I K R L I A G E P Q K A L A P W Y K N F R G K I I Q I D P S R F A C Y G E V A V L D D N T I E I T E L P I K Q W T Q D Y K E K V L E G L M E S S D K K S P V I V D Y K E Y H T D T T V K F V V K L S P G K L R E L E R G Q D L H Q V F K L Q A V I N T T C M V L F D A A G C L R T Y T S P E A I T Q E F Y D S R Q E K Y V Q R K E Y L L G V L Q A Q S K R L T N Q A R F I L A K I N N E I V L E N K K K A A I V D V L I K M K F D A D P V K K W K E E Q K L K E L R E S G E I E L D E D D L A A V A V E E D E A I S S A A K A V E T K L S D Y D Y L V G M A L I K L S E E E K N K L I K E S E E K M A E V R V I E K K T W Q D L W H E D L D N F V S E L D K Q E A R E K A D Q D A S I K N A A K K L A A D A K T G R G P K K N V C T E V L P S K D G Q R I E P M L D A A T K A K Y E K M S Q P K K E R V K K E P K E P K E P K K V K K E G Q D I K K F M S P A A P K T A K K E K S D G F N S D M S E E S D V E F D E G I D F D S D D D G V E R E D V V S K P K P R T G K G A A K A E V I D L S D D D E V P A K K P A P A K K A A P K K K K S E F S D L S G G D S D E E A E K K P S T S K K P S P K K A A P K T A E P K S K A V T D F F G A S K K N G K K A A G S D D E D D E S F V V A P R E K S G R A R K A P P T Y D V D S G S D S D Q P K K K R G R V V D S D S D
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 840 840 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157