Uniprot ID	Q306W8
Uniprot Name	POLN_EEEV8
Taxonomy ID	374597
Sequence	M E K V H V D L D A D S P Y V K L L Q K C F P H F E I E A T Q V T D N D H A N A R A F S H L A T K L I E S E V D P D Q V I L D I G S A P V R H T H S K H K Y H C I C P M I S A E D P D R L Q R Y A D K L R K S D V T D R F I A S K A A D L L T V M S T P D V E T P S L C M H T D S T C R Y H G T V A V Y Q D V Y A V H A P T S I Y H Q A L K G V R T I Y W I G F D T T P F M Y K N M A G A Y P T Y N T N W A D E S V L E A R N I G L C S S D L H E K R L G K I S I M R K K K L Q P T N K V V F S V G S T I Y T E E R I L L R S W H L P N V F H L K G K T S F T G R C N T I V S C D G Y V V K K I T I S P G I Y G K V D N L A S T L H R E G F L S C K V T D T L R G E R V S F P V C T Y V P A T L C D Q M T G I L A T D V S V D D A Q K L L V G L N Q R I V V N G R T Q R N T N T M Q N Y L L P V V A Q A F S R W A R E Y R A D L E D E K D L G V R E R S L V M G C C W A F K T H K I T S I Y K K P G T Q T I K K V P A V F N S F V I P Q F N S Y G L N I G L R R R I K M L L E E K R K P A P I I T E A D V A H L K G M Q E E A E A V A E A E A V R A A L P P L L P E V E R E T I E A D I D L I M Q E A G A G S V E T P R R H I K V T T Y P G E E T I G S Y A V L S P Q A V L N S E K L A C I H P L A E Q V L V M T H K G R A G R Y K V E P Y H G R V V V P S G T A I P I P D F Q A L S E S A T I V Y N E R E F V N R Y L H H I A I N G G A I N T D E E Y Y K V L R S S E A D S E Y V F D I D A R K C V K K A D A G P M C L V G E L V D P P F H E F A Y E S L K T R P A A P H K V P T I G V Y G V P G S G K S G I I K S A V T K R D L V V S A K K E N C T E I I K D V K R M R G M D I A A R T V D S V L L N G V K H P V D T L Y I D E A F A C H A G T L L A L I A I V K P K K V V L C G D P K Q C G F F N M M C L K V H F N H E I C T E V Y H K S I S R R C T K T V T A I V S T L F Y D K R M R T V N P C S D K I I I D T T S T T K P Q R D D I I L T C F R G W V K Q L Q I D Y K N H E I M T A A A S Q G L T R K G V Y A V R Y K V N E N P L Y A Q T S E H V N V L L T R T E K R I V W K T L A G D P W I K T L T A H Y P G E F S A T L E E W Q A E H D A I M E R I L E T P A S S D V Y Q N K V H V C W A K A L E P V L A T A N I T L T R S Q W E T I P A F K D D K A F S P E M A L N F L C T R F F G V D I D S G L F S A P T V P L T Y T N E H W D N S P G P N R Y G L C M R T A K E L A R R Y P C I L K A V D T G R L A D V R T N T I K D Y S P L I N V V P L N R R L P H S L V V S H R Y T G D G N Y S Q L L S K L I G K T V L V I G T P I S V P G K R V E T L G P G P Q C T Y K A D L D L G I P S T I G K Y D I I F V N V R T P Y K H H H Y Q Q C E D H A I H H S M L T R K A V D H L N K G G T C V A L G Y G T A D R A T E N I I S A V A R S F R F S R V C Q P K C A W E N T E V A F V F F G K D N G N H L R D Q D Q L S I V L N N I Y Q G S T Q Y E A G R A P A Y R V I R G D I S K S T D E A I V N A A N N K G Q P G A G V C G A L Y K K W P G A F D K V P I A T G T A H L V K H T P N I I H A V G P N F S R V S E V E G N Q K L S E V Y M D I A K I I N R E R Y N K V S I P L L S T G I Y A G G K D R V M Q S L N H L F T A M D T T D A D V T I Y C L D K Q W E A R I K D A I A R K E S V E E L V E D D K P V D I E L V R V H P L S S L V G R P G Y S T D E G K V H S Y L E G T R F H Q T A K D I A E I Y A M W P N K Q E A N E Q I C L Y V L G E S M T S I R S K C P V E D S E A S S P P H T I P C L C N Y A M T A E R V Y R L R M A K N E Q F A V C S S F Q L P K Y R I T G V Q K I Q C N K P V I F S G V V P P A I H P R K F S A I E E T V P V T I E R L V P R R P A P P V P V P A R I P S P R C S P A V S M Q S L G G S S T S D V V I S E A E V H D S D S D C S I P P M P F V V E A E V H A S Q G S H W S I P S A S G F E I R E L P E D R S I S G S P T R T S V I S D H S V N L I T F D S V T D I F E N F K Q A P F Q F L S E I R P I P A P R R R V G G F E T D T K R Y D K T E E K P I P K P R T R T T K Y K Q P P G V A R S I S E A E L D E F I R R H S N X R Y E A G A Y I F S S E T G Q G H L Q Q K S T R Q C K L Q N P I L E R S V H E K F Y A P R L D L E R E K L L Q K K L Q L C A S E G N R S R Y Q S R K V E N M K A I T A E R L L Q G I G A Y L S A E S Q P V E C Y K V N Y P V P I Y S T T R S N R F S S A D V A V R V C N L V L Q E N F P T V A S Y T I T D E Y D A Y L D M V D G A S C C L D T A T F C P A K L R S F P K K H S Y L R P E I R S A V P S P I Q N T L Q N V L A A A T K R N C N V T Q M R E L P V L D S A A F N V E C F K K Y A C N D E Y W D T F K N N P I R L T T E N V T Q Y V T K L K G P K A A A L F A K T H N L Q P L H E I P M D R F V M D L K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L N A V L L P N I H T L F D M S A E D F D A I I A E H F Q F G D A V L E T D I A S F D K S E D D A I A M S A L M I L E D L G V D Q A L L D L I E A A F G N I T S V H L P T G T R F K F G A M M K S G M F L T L F I N T V V N I M I A S R V L R E R L T N S P C A A F I G D D N I V K G V K S D A L M A E R C A T W L N M E V K I I D A T V G V K A P Y F C G G F I V V D Q V T G T A C R V A D P L K R L F K L G K P L P L D D D Q D G D R R R A L Y D E A L R W N R I G I T D E L I K A V E S R Y E V F Y I S L V I T A L T T L A A T V S N F K Y I R G N P I T L Y G
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1010 1010 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1079 1079 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR001788