Uniprot ID	Q4R6M8
Uniprot Name	TKTL1_MACFA
Taxonomy ID	9541
Sequence	M A D A E A S A E L P E E A R P D G G T L R V L R D M A S R L R I H S I R A T C S T S S G H P T S C S S S A E I M S V L F F Y I M R Y K Q S D P E N P D N D R F V L A K R L S F V D V A T G W L G Q G L G V A C G M A Y T G K Y F D R A S Y R V F C L M S D G E S S E G S V W E A M A F A S Y Y S L D N L V A I F D V N R L G H S G A L P A E H C I D I Y Q R R C E A F G W N T Y V V D G R D V E A L C Q V F W Q A S Q V K H K P T A V V A K T F K G R G T P S I E D A E S W H G K P M P R E R A D A I I K L I E S Q I E T S R N L D P Q L P I E D S P E V N I T D V R M T S P P D Y R V G D K I A T R K A C G L A L A K L G Y A N D R V I V L D G D T K Y S T F S E I F N K E Y P E R F I E C F M A E Q N M V S V A L G C A S R G R T I A F A S T F A A F L T R A F D Q I R I G G L S E S N I N I I G S H C G V S V G E D G A S Q M A L E D I A M F R T I P K C T I F Y P T D A V S T E H A V S L A A N A K G M C F I R T T R P E T M V I Y T P Q E R F E I G Q A K V L R H C V S D K V T V I G A G I T V Y E A L A A A D E L L K Q D I F I R V I D L F T I K P L D V T T I I S S A K A T E G R I I T V E D H Y P Q G G I G E A V C A A V S M D P D I Q V H S L A V S G V P Q S G K S E E L L D M Y G I S A R H I I V A V K C M L L N
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 340 340 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR020826 IPR033248 IPR005474