Uniprot ID	Q4UM42
Uniprot Name	TOP1_RICFE
Taxonomy ID	315456
Sequence	M K L V I V E S P A K A K T I N K Y L G D E F K V I A S F G H I R D L P S K K G S V L P D E N F A M K Y D I S D K A G K Y V D A I V K D A K K A D A V Y L A T D P D R E G E A I S W H V A E V I K E K N K V K S D D F F K R V A F N E I T K K A I I H A V E N P R K L D A N L V N A Q Q A R R A L D Y L V G F T L S P L L W R K L P G C K S A G R V Q S V A L R L I C E R E D E I E R F K S E E Y W D I S L K M Q N S N N E L F T A K L T H V N D Q K L E K F S I I N E K D A K D L T E K L K S Q N F H V D K I E K K Q Q K R Q P Q P P F I T S S L Q Q E A A R K L G F S A K K T M Q I A Q K L Y E G V D I G K E T I G L I T Y M R T D G V T L S N D A I A D I R K L I D K N Y G D K Y L P N S P R I Y K S K V K N A Q E A H E A I R P T N I T Y T P D S L K E K L E K D Y Y K L Y E L I W K R T I A C Q M E N V I M D L V V A S L A S E N K E Y L A K A N G S T I A F D G F Y K V Y R E S V D D E A E E E N K M L P P L K E Q E P L K T K E I I P N Q H F T E P P P R Y S E A S L V K K L E E L G I G R P S T Y A S I L S V L Q D R K Y V S L E K K R F M P E E L G R L V T V F L V G F F K K Y V E Y D F T A G L E N E L D E I A A G K L E W K A A L N N F W S G F N H N I E S V N E Q K I T E I I S Y V Q K A L D Y H L F S E N K E S K A C P S C K T G E L S L K L G K F G A F L A C S N Y P E C T F R K S I V S G N D N N E N D G D L A A T P N E N K V L G T D K D G I E I Y L K K G P Y G P Y V Q L G E Q E G K V K P K R S P V P A S L N Q N D I T L E M A L K L L S L P L K I G I H K D S G E E I M I G Y G K F G P Y I K Y M G K F I S I P K K Y D F L N L S L D D A M K L I E D N K A K L E K K Q A
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952};
Active site	ACT_SITE 304 304 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}.
Pfam	PF01131 PF01751 PF13368 PF01396
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR013498 IPR005733 IPR028612 IPR025589 IPR006171 IPR034149