Uniprot ID	Q55BP5
Uniprot Name	TOP2_DICDI
Taxonomy ID	44689
Sequence	M S D S E N D Y S D E S S G S E Y E S P V K K G K S A P K K P A A A G S K K K A S A T R K P A A K K A T T T T T S T T K K S T T S K K S E S D N D D F S G D D K S S S S D N E N V F K N I A S S A K K G K S I E E I Y Q K K E L L D Q I L L R P D T Y I G S T E R Q E E E L W V W E D K R M V H R K V S F V P G I Y K I F D E I L V N A A D N K Q R E G N M K F I K V V I D R E K G F I S V T N D G A G I P I Q V H S E H K I Y I P E L I F G N L L T S S H Y D D S E K R L T G G R N G F G A K L A N I F S T K F I V E C A D S K S K K L Y K Q T F T N N M R S K E D P K I T S Y Q N K T D Y T K I T F Y P E L D R F G M V E F D D D L V A L L S K R V Y D I A G C N P T L K V S L N D E E L G I R S F E K Y I N L Y F P D E E N A P K V Y Y E K V S D R W E L A V T L S K E S Q F N Q V S F V N S I C T V K G G T H V T H A L S N I V T A I Q E Q V N K K N K G S A D I K P A F I K N H L S V F V N C L I E N P H F D S Q T K E T L T S K I S S F G S R C E P S E K F I K R V L D S K S G I V A S I L E F A Q F K D Q S A L K R S T S S G G K K G K V S I P K L D D A N L A G G T K S E D C T L I L T E G D S A K S L A T A G I S V V G K D H Y G A F P L K G K L L N V R D Q S T K V I N N D E I N N I V T I L G L K Y G K V Y E T L S D L R Y G H L M I M T D Q D H D G S H I K G L I I N M V H H F W P T L L R M P G F L V E F I T P I V K V F K N N Q K P I S F Y T M P E F L K W R E T N D K G W D V K Y Y K G L G T S T P G E G K E Y F S D L E R H K I D F E W D E G A N D N I E L A F S K S R A D D R K K W M A E H I E G T F L E Q F G V K K L T Y S D F I N K E L V L F S I A D C E R S I P N I V D G L K T S H R K T L Y S C F K R N L K K E I K V A Q L I G Y V S E H S A Y H H G E A S L Y S T I V G M A Q E F V G S N N I N L L N P A G S Y G T R I A G G K D C S S A R Y I H T R L N D I A R A V Y H A D D D P I L S C V V D D G K K V Q P K F Y I P V I P M I L V N G C V G I G T G W S S T I P N Y N P R D L I Q N M R L A I D G K P L K P I K P W Y R G F L G S I E A N Q G S K V Q G G Q Y L S K G I W K K L S D N R F E I T E L P I G F W T Q D Y R E L L D E L E T P G T R K K K K E E K E K K A A S R K G T K A K P T T T K R S K R V D D D D D N E K V T E A T V K S Y T N Y S S E S T I H F I I D T I Q P V D E I N I E K V F K L V S T I N E T N M V V F D E E G R I Q R F A T T T A L Q E H F F P L R I K H Y Q M R K D F L S E R L S E E Y S R L S N K A R F I L A V V N K E L V I S N V K K V D L I N K L K E M K F D R I I N K N S N K S A R D K I K K K K N A F D E E D A A I S S D E E K D G A Q E E Q D D D T K G Y D Y L L S L P L W S L T L E R V K K L I E E R D S K K K E W D I L L S T P I Q E I Y K R D L D A L E K A L D D Q D A Y D E S L K N Q T E S L K K R T K T K A L P R A K K I S A K V V K D T K E A P L T K L V K P T V K I P T T T D S N V S G S K R K K S D D T T S T S T S T T T S S N T K P I E S F F A K E D K K P T P A V K K S T L V S L D S D S D F D D D V V V S S K P K A P P K K T S K V I E L S D E S D Q E S D Q E S D Q G S D P E S P P K R S K A P P K K P T T I A T K K A T T S K S K V I D D K S S D D E V I K A P T N R P T R S R V P P P K S L S F L D S D S D D D D L Y D N E E S S S D S D
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 861 861 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157