Uniprot ID	Q57815
Uniprot Name	TOP6A_METJA
Taxonomy ID	243232
Sequence	M V K L P A I S K K P R E I A K Q K I I E L A K K M Y E D L M K G K R P K I T M P I R S L S N A M F D K E K G S F T L V G K E K A R T L T V N Q A K I F A Q T T K M L E F A K Q L L E T D D F S T L R E A Y Y V S K N W G E A R F D D Q Q A S N N V I E D L E A A L G V L R E H L G F I P E E D G S S V V G P L K I I E E T P E G E L V V D C T K L G T G A Y N I P N D V T K L N L E T D A D F I L A I E T S G M F A R L N A E R F W D K H N C I L V S L K G V P A R A T R R F I K R L H E E H D L P V L V F T D G D P Y G Y L N I Y R T L K V G S G K A I H L A D K L S I P A A R L I G V T P Q D I I D Y D L P T H P L K E Q D I K R I K D G L K N D D F V R S F P E W Q K A L K Q M L D M G V R A E Q Q S L A K Y G L K Y V V N T Y L P E K I K D E S T W L P
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00132, ECO:0000269|PubMed:10545127}; Note=Mg(2+) is directly coordinated by Glu-197 and Asp-249 as well as indirectly coordinated through 2 water molecules by Asp-251 (PubMed:10545127). {ECO:0000269|PubMed:10545127};
Active site	ACT_SITE 103 103 Nucleophile. {ECO:0000250|UniProtKB:Q9M4A2}.
Pfam	PF04406
InterPro	IPR002815 IPR013049 IPR036078 IPR004085 IPR034136 IPR036388