Uniprot ID | Q59046 |
Uniprot Name | TOP1_METJA |
Taxonomy ID | 243232 |
Sequence |
M
A
E
I
M
T
A
L
I
I
C
E
K
P
S
V
A
K
K
I
A
N
A
L
G
K
A
K
K
K
S
I
D
G
V
P
Y
Y
E
L
E
R
D
G
K
K
I
I
V
A
S
A
V
G
H
L
F
T
L
V
E
K
E
N
K
E
F
G
F
Y
P
V
F
D
I
K
W
V
P
A
S
V
D
K
G
K
E
Y
V
N
K
Y
I
K
A
L
K
K
L
S
K
D
A
D
E
F
Y
I
A
T
D
W
D
I
E
G
E
L
I
G
Y
H
A
L
K
Y
C
C
G
R
E
K
A
K
R
M
R
F
S
S
L
T
K
K
E
I
V
R
A
F
E
N
P
D
E
I
D
Y
G
L
V
D
A
G
E
S
R
H
I
L
D
W
Y
F
G
I
N
L
S
R
A
L
M
N
A
I
R
A
V
N
R
W
K
T
M
S
V
G
R
V
Q
G
P
A
L
A
F
L
T
E
R
E
L
E
I
K
K
F
I
P
K
P
Y
W
V
I
E
A
L
L
K
D
N
L
K
A
I
H
E
K
E
K
F
W
N
E
K
E
A
K
N
V
Y
E
K
I
K
D
E
K
S
A
K
V
V
E
I
K
K
T
K
R
K
L
K
P
L
P
P
F
D
L
G
T
L
Q
R
E
A
Y
S
Y
F
K
I
S
P
K
E
T
Q
E
I
A
Q
K
L
Y
E
N
A
L
I
S
Y
P
R
T
S
S
Q
K
L
P
K
D
R
K
Y
L
E
D
I
L
N
I
I
K
N
H
P
V
Y
G
K
W
A
E
R
I
L
K
E
N
L
K
P
V
E
G
K
K
E
D
P
A
H
P
A
I
H
I
V
D
I
P
K
E
E
L
S
E
K
E
K
E
I
Y
D
L
I
A
R
R
T
L
A
A
F
W
D
N
A
E
R
E
Y
L
N
V
K
I
D
I
K
G
E
K
F
K
L
S
G
S
R
T
V
K
E
G
W
H
E
I
Y
Y
F
P
K
F
D
E
I
E
L
P
P
L
K
K
N
D
I
I
K
V
E
K
I
T
I
T
R
K
E
T
Q
P
P
K
R
Y
T
V
A
S
I
I
K
E
L
E
K
R
G
L
G
T
K
A
T
R
A
E
I
I
D
K
L
I
K
R
G
Y
V
I
D
D
G
S
L
K
V
T
D
L
G
I
S
V
I
E
T
L
K
R
F
C
P
E
I
I
D
E
K
M
T
R
D
L
E
E
K
L
E
K
I
Q
F
R
K
I
K
K
D
D
V
L
D
E
A
E
K
R
L
R
K
I
L
E
E
F
K
K
K
E
E
D
I
G
I
Y
L
I
K
N
L
D
A
T
N
K
K
A
K
I
V
G
K
C
P
K
C
G
G
D
L
I
L
I
R
H
K
K
G
R
F
V
G
C
S
N
Y
P
E
C
D
V
K
Y
S
L
P
D
K
G
R
I
K
I
P
N
K
V
C
D
A
C
K
S
P
I
L
K
I
G
D
R
E
I
C
I
N
P
E
C
P
L
K
Q
V
E
V
K
E
E
D
R
I
C
P
K
C
G
A
K
L
I
L
K
K
G
V
Y
G
A
F
Y
G
C
S
N
Y
P
K
C
K
Y
T
E
P
I
N
K
K
E
V
V
G
K
C
P
K
C
G
G
D
L
V
V
R
E
G
K
F
G
K
F
V
G
C
S
N
Y
P
K
C
R
Y
T
E
K
L
K
L
N
E
K
E
E
K
|
Cofactor |
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952}; |
Active site |
ACT_SITE 315 315 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}. |
Pfam |
PF01131
PF01751
PF01396
|
InterPro |
IPR000380
IPR003601
IPR023406
IPR013497
IPR013824
IPR013825
IPR013826
IPR023405
IPR003602
IPR013498
IPR005739
IPR028612
IPR006171
IPR034144
|