Uniprot ID	Q5S007
Uniprot Name	LRRK2_HUMAN
Taxonomy ID	9606
Sequence	M A S G S C Q G C E E D E E T L K K L I V R L N N V Q E G K Q I E T L V Q I L E D L L V F T Y S E R A S K L F Q G K N I H V P L L I V L D S Y M R V A S V Q Q V G W S L L C K L I E V C P G T M Q S L M G P Q D V G N D W E V L G V H Q L I L K M L T V H N A S V N L S V I G L K T L D L L L T S G K I T L L I L D E E S D I F M L I F D A M H S F P A N D E V Q K L G C K A L H V L F E R V S E E Q L T E F V E N K D Y M I L L S A L T N F K D E E E I V L H V L H C L H S L A I P C N N V E V L M S G N V R C Y N I V V E A M K A F P M S E R I Q E V S C C L L H R L T L G N F F N I L V L N E V H E F V V K A V Q Q Y P E N A A L Q I S A L S C L A L L T E T I F L N Q D L E E K N E N Q E N D D E G E E D K L F W L E A C Y K A L T W H R K N K H V Q E A A C W A L N N L L M Y Q N S L H E K I G D E D G H F P A H R E V M L S M L M H S S S K E V F Q A S A N A L S T L L E Q N V N F R K I L L S K G I H L N V L E L M Q K H I H S P E V A E S G C K M L N H L F E G S N T S L D I M A A V V P K I L T V M K R H E T S L P V Q L E A L R A I L H F I V P G M P E E S R E D T E F H H K L N M V K K Q C F K N D I H K L V L A A L N R F I G N P G I Q K C G L K V I S S I V H F P D A L E M L S L E G A M D S V L H T L Q M Y P D D Q E I Q C L G L S L I G Y L I T K K N V F I G T G H L L A K I L V S S L Y R F K D V A E I Q T K G F Q T I L A I L K L S A S F S K L L V H H S F D L V I F H Q M S S N I M E Q K D Q Q F L N L C C K C F A K V A M D D Y L K N V M L E R A C D Q N N S I M V E C L L L L G A D A N Q A K E G S S L I C Q V C E K E S S P K L V E L L L N S G S R E Q D V R K A L T I S I G K G D S Q I I S L L L R R L A L D V A N N S I C L G G F C I G K V E P S W L G P L F P D K T S N L R K Q T N I A S T L A R M V I R Y Q M K S A V E E G T A S G S D G N F S E D V L S K F D E W T F I P D S S M D S V F A Q S D D L D S E G S E G S F L V K K K S N S I S V G E F Y R D A V L Q R C S P N L Q R H S N S L G P I F D H E D L L K R K R K I L S S D D S L R S S K L Q S H M R H S D S I S S L A S E R E Y I T S L D L S A N E L R D I D A L S Q K C C I S V H L E H L E K L E L H Q N A L T S F P Q Q L C E T L K S L T H L D L H S N K F T S F P S Y L L K M S C I A N L D V S R N D I G P S V V L D P T V K C P T L K Q F N L S Y N Q L S F V P E N L T D V V E K L E Q L I L E G N K I S G I C S P L R L K E L K I L N L S K N H I S S L S E N F L E A C P K V E S F S A R M N F L A A M P F L P P S M T I L K L S Q N K F S C I P E A I L N L P H L R S L D M S S N D I Q Y L P G P A H W K S L N L R E L L F S H N Q I S I L D L S E K A Y L W S R V E K L H L S H N K L K E I P P E I G C L E N L T S L D V S Y N L E L R S F P N E M G K L S K I W D L P L D E L H L N F D F K H I G C K A K D I I R F L Q Q R L K K A V P Y N R M K L M I V G N T G S G K T T L L Q Q L M K T K K S D L G M Q S A T V G I D V K D W P I Q I R D K R K R D L V L N V W D F A G R E E F Y S T H P H F M T Q R A L Y L A V Y D L S K G Q A E V D A M K P W L F N I K A R A S S S P V I L V G T H L D V S D E K Q R K A C M S K I T K E L L N K R G F P A I R D Y H F V N A T E E S D A L A K L R K T I I N E S L N F K I R D Q L V V G Q L I P D C Y V E L E K I I L S E R K N V P I E F P V I D R K R L L Q L V R E N Q L Q L D E N E L P H A V H F L N E S G V L L H F Q D P A L Q L S D L Y F V E P K W L C K I M A Q I L T V K V E G C P K H P K G I I S R R D V E K F L S K K R K F P K N Y M S Q Y F K L L E K F Q I A L P I G E E Y L L V P S S L S D H R P V I E L P H C E N S E I I I R L Y E M P Y F P M G F W S R L I N R L L E I S P Y M L S G R E R A L R P N R M Y W R Q G I Y L N W S P E A Y C L V G S E V L D N H P E S F L K I T V P S C R K G C I L L G Q V V D H I D S L M E E W F P G L L E I D I C G E G E T L L K K W A L Y S F N D G E E H Q K I L L D D L M K K A E E G D L L V N P D Q P R L T I P I S Q I A P D L I L A D L P R N I M L N N D E L E F E Q A P E F L L G D G S F G S V Y R A A Y E G E E V A V K I F N K H T S L R L L R Q E L V V L C H L H H P S L I S L L A A G I R P R M L V M E L A S K G S L D R L L Q Q D K A S L T R T L Q H R I A L H V A D G L R Y L H S A M I I Y R D L K P H N V L L F T L Y P N A A I I A K I A D Y G I A Q Y C C R M G I K T S E G T P G F R A P E V A R G N V I Y N Q Q A D V Y S F G L L L Y D I L T T G G R I V E G L K F P N E F D E L E I Q G K L P D P V K E Y G C A P W P M V E K L I K Q C L K E N P Q E R P T S A Q V F D I L N S A E L V C L T R R I L L P K N V I V E C M V A T H H N S R N A S I W L G C G H T D R G Q L S F L D L N T E G Y T S E E V A D S R I L C L A L V H L P V E K E S W I V S G T Q S G T L L V I N T E D G K K R H T L E K M T D S V T C L Y C N S F S K Q S K Q K N F L L V G T A D G K L A I F E D K T V K L K G A A P L K I L N I G N V S T P L M C L S E S T N S T E R N V M W G G C G T K I F S F S N D F T I Q K L I E T R T S Q L F S Y A A F S D S N I I T V V V D T A L Y I A K Q N S P V V E V W D K K T E K L C G L I D C V H F L R E V M V K E N K E S K H K M S Y S G R V K T L C L Q K N T A L W I G T G G G H I L L L D L S T R R L I R V I Y N F C N S V R V M M T A Q L G S L K N V M L V L G Y N R K N T E G T Q K Q K E I Q S C L T V W D I N L P H E V Q N L E K H I E V R K E L A E K M R R T S V E
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462};
Active site	ACT_SITE 1994 1994 Proton acceptor. {ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027}.
Pfam	PF16095 PF13855 PF00069
InterPro	IPR036770 IPR011989 IPR016024 IPR032171 IPR011009 IPR001611 IPR003591 IPR032675 IPR027417 IPR000719 IPR017441 IPR020859 IPR008271 IPR005225 IPR015943 IPR036322