Uniprot ID	Q5XXP4
Uniprot Name	POLN_CHIK3
Taxonomy ID	371095
Sequence	M D P V Y V D I D A D S A F L K A L Q R A Y P M F E V E P R Q V T P N D H A N A R A F S H L A I K L I E Q E I D P D S T I L D I G S A P A R R M M S D R K Y H C V C P M R S A E D P E R L A N Y A R K L A S A A G K V L D R N I S E K I G D L Q A V M A V P D A E T P T F C L H T D V S C R Q R A D V A I Y Q D V Y A V H A P T S L Y H Q A I K G V R V A Y W I G F D T T P F M Y N A M A G A Y P S Y S T N W A D E Q V L K A K N I G L C S T D L T E G R R G K L S I M R G K K M K P C D R V L F S V G S T L Y P E S R K L L K S W H L P S V F H L K G K L S F T C R C D T V V S C E G Y V V K R I T I S P G L Y G K T T G Y A V T H H A D G F L M C K T T D T V D G E R V S F S V C T Y V P A T I C D Q M T G I L A T E V T P E D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P V V A Q A F S K W A K E C R K D M E D E K L L G I R E R T L T C C C L W A F K K Q K T H T V Y K R P D T Q S I Q K V P A E F D S F V V P S L W S S G L S I P L R T R I K W L L S K V P K T D L I P Y S G D A K E A R D A E K E A E E E R E A E L T R E A L P P L Q A A Q D D V Q V E I D V E Q L E D R A G A G I I E T P R G A I K V T A Q P T D H V V G E Y L V L S P Q T V L R S Q K L S L I H A L A E Q V K T C T H S G R A G R Y A V E A Y D G R I L V P S G Y A I S P E D F Q S L S E S A T M V Y N E R E F V N R K L H H I A L H G P A L N T D E E S Y E L V R A E R T E H E Y V Y D V D Q R R C C K K E E A A G L V L V G D L T N P P Y H E F A Y E G L R I R P A C P Y K T A V I G V F G V P G S G K S A I I K N L V T R Q D L V T S G K K E N C Q E I S T D V M R Q R N L E I S A R T V D S L L L N G C N R P V D V L Y V D E A F A C H S G T L L A L I A L V R P R Q K V V L C G D P K Q C G F F N M M Q M K V N Y N H N I C T Q V Y H K S I S R R C T L P V T A I V S S L H Y E G K M R T T N E Y N K P I V V D T T G S T K P D P G D L V L T C F R G W V K Q L Q I D Y R G H E V M T A A A S Q G L T R K G V Y A V R Q K V N E N P L Y A S T S E H V N V L L T R T E G K L V W K T L S G D P W I K T L Q N P P K G N F K A T I K E W E V E H A S I M A G I C N H Q V T F D T F Q N K A N V C W A K S L V P I L E T A G I K L N D R Q W S Q I I Q A F K E D R A Y S P E V A L N E I C T R M Y G V D L D S G L F S K P L V S V H Y A D N H W D N R P G G K M F G F N P E A A S I L E R K Y P F T K G K W N T N K Q I C V T T R R I E D F N P N T N I I P A N R R L P H S L V A E H R P V K G E R M E W L V N K I N G H H V L L V S G Y N L V L P T K R V T W V A P L G I R G A D Y T Y N L E L G L P A T L G R Y D L V I I N I H T P F R I H H Y Q Q C V D H A M K L Q M L G G D S L R L L K P G G S L L I R A Y G Y A D R T S E R V V C V L G R K F R S S R A L K P P C V T S N T E M F F L F S N F D N G R R N F T T H V M N N Q L N A A F V G Q A T R A G C A P S Y R V K R M D I A K N D E E C V V N A A N P R G L P G D G V C K A V Y K K W P E S F K N S A T P V G T A K T V M C G T Y P V I H A V G P N F S N Y S E S E G D R E L A A A Y R E V A K E V T R L G V N S V A I P L L S T G V Y S G G K D R L T Q S L N H L F T A L D S T D A D V V I Y C R D K E W E K K I A E A I Q M R T Q V E L L D E H I S V D C D I I R V H P D S S L A G R K G Y S T T E G S L Y S Y L E G T R F H Q T A V D M A E V Y T M W P K Q T E A N E Q V C L Y A L G E S I E S I R Q K C P V D D A D A S S P P K T V P C L C R Y A M T P E R V T R L R M N H V T S I I V C S S F P L P K Y K I E G V Q K V K C S K V M L F D H N V P S R V S P R E Y K S P Q E T A Q E V S S T T S L T H S Q F D L S V D G E E L P A P S D L E A D A P I P E P T P D D R A V L T L P P T I D N F S A V S D W V M N T A P V A P P R R R R G K N L N V T C D E R E G N V L P M A S V R F F R A D L H S I V Q E T A E I R D T A A S L Q A P L S V A T E P N Q L P I S F G A P N E T F P I T F G D F D E G E I E S L S S E L L T F G D F S P G E V D D L T D S D W S T C S D T D D E L X L D R A G G Y I F S S D T G P G H L Q Q R S V R Q T V L P V N T L E E V Q E E K C Y P P K L D E V K E Q L L L K K L Q E S A S M A N R S R Y Q S R K V E N M K A T I V Q R L K G G C K L Y L M S E T P K V P T Y R T T Y P A P V Y S P P I N I R L S N P E S A V A A C N E F L A R N Y P T V A S Y Q I T D E Y D A Y L D M V D G S E S C L D R A T F N P S K L R S Y P K Q H S Y H A P T I R S A V P S P F Q N T L Q N V L A A A T K R N C N V T Q M R E L P T L D S A V F N V E C F K K F A C N Q E Y W K E F A A S P I R I T T E N L T T Y V T K L K G P K A A A L F A K T H N L L P L Q E V P M D R F T V D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L N A V L L P N V H T L F D M S A E D F D A I I A A H F K P G D A V L E T D I A S F D K S Q D D S L A L T A L M L L E D L G V D H P L L D L I E A A F G E I S S C H L P T G T R F K F G A M M K S G M F L T L F V N T L L N I T I A S R V L E D R L T R S A C A A F I G D D N I I H G V V S D E L M A A R C A T W M N M E V K I I D A V V S Q K A P Y F C G G F I L Y D T V A G T A C R V A D P L K R L F K L G K P L A A G D E Q D D D R R R A L A D E V V R W Q R T G L T D E L E K A V H S R Y E V Q G I S V V V M S M A T F A S S R S N F E K L R G P V V T L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1013 1013 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1083 1083 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR001788