Uniprot ID	Q5Y389
Uniprot Name	POLN_GETV
Taxonomy ID	59300
Sequence	M K V T V D V E A D S P F L K A L Q K A F P A F E V E S Q Q V T P N D H A N A R A F S H L A T K L I E Q E V P T G V T I L D V G S A P A R R L M S D H T Y H C I C P M K S A E D P E R L A N Y A R K L A K A S G T V L D K N V S G K I T D L Q D V M A T P D L E S P T F C L H T D E T C R T R A E V A V Y Q D V Y A V H A P T S L Y H Q A I K G V R T A Y W I G F D T T P F M F E A L A G A Y P A Y S T N W A D E Q V L Q A R N I G L C A T G L S E G R R G K L S I M R K K C L R P S D R V M F S V G S T L Y T E S R K L L R S W H L P S V F H L K G K N S F T C R C D T V V S C E G Y V V K K I T I S P G I Y G K T V D Y A V T H H A E G F L M C K I T D T V R G E R V S F P V C T Y V P A T I C D Q M T G I L A T D V T P E D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P V V A Q A F S K W A R E A R A D M E D E K P L G T R E R T L T C C C L W A F K S H K I H T M Y K R P E T Q T I V K V P S T F D S F V I P S L W S S S L S M G I R Q R I K L L L S A R M A Q G L P Y S G D R T E A R A A E E E E K E V Q E A E L T R A A L P P L V S G S C A D D I A Q V D V E E L T F R A G A G V V E T P R N A L K V T P Q A H D H L I G S Y L I L S P Q T V L K S E K L A P I H P L A E Q V T V M T H S G R S G R Y P V D K Y D G R V L I P T G A A I P V S E F Q A L S E S A T M V Y N E R E F I N R K L H H I A L Y G P A L N T D E E S Y E K V R A E R A E T E Y V F D V D K K A C I K K E E A S G L V L T G D L I N P P F H E F A Y E G L K I R P A A P Y H T T I I G V F G V P G S G K S A I I K N M V T T R D L V A S G K K E N C Q E I M N D V K R Q R G L D V T A R T V D S I L L N G C K K G V E N L Y V D E A F A C H S G T L L A L I A L V R P S G K V V L C G D P K Q C G F F N L M Q L K V H Y N H N I C T R V L H K S I S R R C T L P V T A I V S T L H Y Q G K M R T T N R C N T P I Q I D T T G S S K P A S G D I V L T C F R G W V K Q L Q I D Y R G H E V M T A A A S Q G L T R K G V Y A V R Q K V N E N P L Y S P L S E H V N V L L T R T E N R L V W K T L S G D P W I K V L T N V P R G D F S A T L E E W H E E H D G I M R V L N E R P A E V D P F Q N K A K V C W A K C L V Q V L E T A G I R M T A D E W N T I L A F R E D R A Y S P E V A L N E I C T R Y Y G V D L D S G L F S A Q S V S L F Y E N N H W D N R P G G R M Y G F N H E V A R K Y A A R F P F L R G N M N S G L Q L N V P E R K L Q P F S A E C N I V P S N R R L P H A L V T S Y Q Q C R G E R V E W L L K K I P G H Q M L L V S E Y N L V I P H K R V F W I A P P R V S G A D R T Y D L D L G L P M D A G R Y D L V F V N I H T E Y R Q H H Y Q Q C V D H S M R L Q M L G G D S L H L L R P G G S L L M R A Y G Y A D R V S E M V V T A L A R K F S A F R V L R P A C V T S N T E V F L L F S N F D N G R R A V T L H Q A N Q K L S S M Y A C N G L H T A G C A P S Y R V R R A D I S G H S E E A V V N A A N A K G T V S D G V C R A V A K K W P S S F K G A A T P V G T A K M I R A D G M T V I H A V G P N F S T V T E A E G D R E L A A A Y R A V A S I I S T N N I K S V A V P L L S T G T F S G G K D R V M Q S L N H L F T A L D A T D A D V V I Y C R D K N W E K K I Q E A I D R R T A I E L V S E D V T L E T D L V R V H P D S C L V G R N G Y S A T D G K L Y S Y L E G T R F H Q T A V D M A E I S T L W P R L Q D A N E Q I C L Y A L G E T M D S I R T K C P V E D A D S S T P P K T V P C L C R Y A M T A E R V A R L R M N N T K N I I V C S S F P L P K Y R I E G V Q K V K C D R V L I F D Q T V P S L V S P R K Y I Q Q P P E Q L D N V S L T S T T S T G S A W S F P S E T T Y E T M E V V A E V H T E P P I P P P R R R R A A V A Q L R Q D L E V T E E I E P Y V T Q Q A E I M V M E R V A T T D I R A I P V P A R R A I T M P V P A P R V R K V A T E P P L E P E A P I P A P R K R R T T S T S P P H N P E D F V P R V P V E L P W E P E D L D I Q F G D L E P R R R N T R D R D V S T G I Q F G D I D F N Q S X L G R A G A Y I F S S D T G P G H L Q Q K S V R Q H E L P C E T L Y A H E D E R I Y P P A F D G E K E K V L Q A K M Q M A P T E A N K S R Y Q S R K V E N M K A L I V E R L R E G A K L Y L H E Q T D K V P T Y T S K Y P R P V Y S P S V D D S L S D P E V A V A A C N S F L E E N Y P T V A N Y Q I T D E Y D A Y L D L V D G S E S C L D R A T F C P A K L R C Y P K H H A Y H Q P Q I R S A V P S P F Q N T L Q N V L A A A T K R N C N V T Q M R E L P T M D S A V F N V E S F K K Y A C T G E Y W Q E F K D N P I R I T T E N I T T Y V A K L K G P K A A A L F A K T H N L V P L Q E V P M D R F V M D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L K A V L T P N I H T L F D M S A E D F D A I I A A H F Q P G D A V L E T D I A S F D K S Q D D S L A L T A L M L L E D L G V D Q E L L D L I E A A F G E I T S V H L P T G T R F K F G A M M K S G M F L T L F I N T L L N I V I A C R V L R D K L S S S A C A A F I G D D N I V H G V R S D P L M A E R C A S W V N M E V K I I D A T M C E K P P Y F C G G F I L Y D S V A G T A C R V A D P L K R L F K L G K P L P A D D N Q D E D R R R A L K D E T V K W S R I G L R E E L D V A L S S R Y Q V S G V G N I T R A M S T L S K S L K S F R K I R G P I I H L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1012 1012 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1081 1081 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR001788