Uniprot ID	Q64374
Uniprot Name	RGN_MOUSE
Taxonomy ID	10090
Sequence	M S S I K V E C V L R E N Y R C G E S P V W E E A S Q S L L F V D I P S K I I C R W D T V S N Q V Q R V A V D A P V S S V A L R Q L G G Y V A T I G T K F C A L N W E N Q S V F V L A M V D E D K K N N R F N D G K V D P A G R Y F A G T M A E E T A P A V L E R H Q G S L Y S L F P D H S V K K Y F D Q V D I S N G L D W S L D H K I F Y Y I D S L S Y T V D A F D Y D L Q T G Q I S N R R I V Y K M E K D E Q I P D G M C I D A E G K L W V A C Y N G G R V I R L D P E T G K R L Q T V K L P V D K T T S C C F G G K D Y S E M Y V T C A R D G L N A E G L L R Q P D A G N I F K I T G L G V K G I A P Y S Y A G
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+). {ECO:0000250};
Active site	ACT_SITE 204 204 Proton donor/acceptor. {ECO:0000305|PubMed:23349732}.
Pfam	PF08450
InterPro	IPR011042 IPR008367 IPR013658 IPR005511 IPR039096