Uniprot ID	Q64511
Uniprot Name	TOP2B_MOUSE
Taxonomy ID	10090
Sequence	M A K S S L A G S D G A L T W V N N A T K K E E L E T A N K N D S T K K L S V E R V Y Q K K T Q L E H I L L R P D T Y I G S V E P L T Q L M W V Y D E D V G M N C R E V T F V P G L Y K I F D E I L V N A A D N K Q R D K N M T C I K V S I D P E S N I I S I W N N G K G I P V V E H K V E K V Y V P A L I F G Q L L T S S N Y D D D E K K V T G G R N G Y G A K L C N I F S T K F T V E T A C K E Y K H S F K Q T W M N N M M K T S E A K I K H F D G E D Y T C I T F Q P D L S K F K M E K L D K D I V A L M T R R A Y D L A G S C K G V K V M F N G K K L P V N G F R S Y V D L Y V K D K L D E T G V A L K V I H E L A N E R W D V C L T L S E K G F Q Q I S F V N S I A T T K G G R H V D Y V V D Q V V S K L I E V V K K K N K A G V S V K P F Q V K N H I W V F I N C L I E N P T F D S Q T K E N M T L Q P K S F G S K C Q L S E K F F K A A S N C G I V E S I L N W V K F K A Q T Q L N K K C S S V K Y S K I K G I P K L D D A N D A G G K H S L E C T L I L T E G D S A K S L A V S G L G V I G R D R Y G V F P L R G K I L N V R E A S H K Q I M E N A E I N N I I K I V G L Q Y K K S Y D D A E S L K T L R Y G K I M I M T D Q D Q D G S H I K G L L I N F I H H N W P S L L K H G F L E E F I T P I V K A S K N K Q E L S F Y S I P E F D E W K K H I E N Q K A W K I K Y Y K G L G T S T A K E A K E Y F A D M E R H R I L F R Y A G P E D D A A I T L A F S K K K I D D R K E W L T N F M E D R R Q R R L H G L P E Q F L Y G T A T K H L T Y N D F I N K E L I L F S N S D N E R S I P S L V D G F K P G Q R K V L F T C F K R N D K R E V K V A Q L A G S V A E M S A Y H H G E Q A L M M T I V N L A Q N F V G S N N I N L L Q P I G Q F G T R L H G G K D A A S P R Y I F T M L S S L A R L L F P A V D D N L L K F L Y D D N Q R V E P E W Y I P I I P M V L I N G A E G I G T G W A C K L P N Y D A R E I V N N V R R M L E G L D P H P M L P N Y K N F K G T I Q E L G Q N Q Y A V S G E I F V V D R N T V E I T E L P V R T W T Q V Y K E Q V L E P M L N G T D K T P A L I S D Y K E Y H T D T T V K F V V K M T E E K L A Q A E A A G L H K V F K L Q T T L T C N S M V L F D H M G C L K K Y E T V Q D I L K E F F D L R L S Y Y G L R K E W L V G M L G A E S T K L N N Q A R F I L E K I Q G K I T I E N R S K K D L I Q M L V Q R G Y E S D P V K A W K E A Q E K A A E E E D S Q N Q H D D S S S D S G T P S G P D F N Y I L N M S L W S L T K E K V E E L I K Q R D T K G R E V N D L K R K S P S D L W K E D L A A F V E E L D K V E A Q E R E D I L A G M S G K A I K G K V G K P K V K K L Q L E E T M P S P Y G R R I V P E I T A M K A D A S R K L L K K K K G D P D T T V V K V E F D E E F S G T P A E G T G E E T L T P S A P V N K G P K P K R E K K E P G T R V R K T P T S T G K T N A K K V K K R N P W S D D E S K S E S D L E E A E P V V I P R D S L L R R A A A E R P K Y T F D F S E E E D D D A A A A D D S N D L E E L K V K A S P I T N D G E D E F V P S D G L D K D E Y A F S S G K S K A T P E K S S N D K K S Q D F G N L F S F P S Y S Q K S E D D S A K F D S N E E D T A S V F A P S F G L K Q T D K L P S K T V A A K K G K P P S D T A P K A K R A P K Q K K I V E T I N S D S D S E F G I P K K T T T P K G K G R G A K K R K A S G S E N E G D Y N P G R K P S K T A S K K P K K T S F D Q D S D V D I F P S D F T S E P P A L P R T G R A R K E V K Y F A E S D E E E D V D F A M F N
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q02880, ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q02880, ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250|UniProtKB:Q02880, ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000250|UniProtKB:Q02880, ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 814 814 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250}.
Pfam	PF00204 PF00521 PF08070 PF02518 PF01751 PF16898
InterPro	IPR012542 IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157