Uniprot ID	Q6GHI5
Uniprot Name	TOP1_STAAR
Taxonomy ID	282458
Sequence	M A D N L V I V E S P A K A K T I E K Y L G K K Y K V I A S M G H V R D L P R S Q M G V D T E D N Y E P K Y I T I R G K G P V V K E L K K H A K K A K N V F L A S D P D R E G E A I A W H L S K I L E L E D S K E N R V V F N E I T K D A V K E S F K N P R E I E M N L V D A Q Q A R R I L D R L V G Y N I S P V L W K K V K K G L S A G R V Q S V A L R L V I D R E N E I R N F K P E E Y W T I E G E F R Y K K S K F N A K F L H Y K N K P F K L K T K K D V E K I T A A L D G D Q F E I T N V T K K E K T R N P A N P F T T S T L Q Q E A A R K L N F K A R K T M M V A Q Q L Y E G I D L K K Q G T I G L I T Y M R T D S T R I S D T A K A E A K Q Y I T D K Y G E S Y T S K R K A S G K Q G D Q D A H E A I R P S S T M R T P D D M K S F L T K D Q Y R L Y K L I W E R F V A S Q M A P A I L D T V S L D I T Q G D I K F R A N G Q T I K F K G F M T L Y V E T K D D S D S E K E N K L P K L E Q G D K V T A T Q I E P A Q H Y T Q P P P R Y T E A R L V K T L E E L K I G R P S T Y A P T I D T I Q K R N Y V K L E S K R F V P T E L G E I V H E Q V K E Y F P E I I D V E F T V N M E T L L D K I A E G D I T W R K V I D G F F S S F K Q D V E R A E E E M E K I E I K D E P A G E D C E V C G S P M V I K M G R Y G K F M A C S N F P D C R N T K A I V K S I G V K C P K C N D G D V V E R K S K K N R V F Y G C S K Y P E C D F I S W D K P I G R D C P K C N Q Y L V E N K K G K T T Q V I C S N C D Y K E A A Q K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952};
Active site	ACT_SITE 298 298 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}.
Pfam	PF01131 PF01751 PF01396
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR013498 IPR005733 IPR028612 IPR006171 IPR034149