Uniprot ID	Q6ZVD8
Uniprot Name	PHLP2_HUMAN
Taxonomy ID	9606
Sequence	M K R N G S R N C L N R R S R F G S R E R D W L R E D V K R G C V Y L Y G A D T T T A T T T T T T S S S S S S S S S S S D L H L V L C T V E T P A S E I C A G E G R E S L Y L Q L H G D L V R R L E P T E R P L Q I V Y D Y L S R L G F D D P V R I Q E E A T N P D L G C M I R F Y G E K P C H M D R L D R I L L S G I Y N V R K G K T Q L H K W A E R L V V L C G T C L I V S S V K D C Q T G K M H I L P L V G G K I E E V K R R Q Y S L A F S S A G A Q A Q T Y H V S F E T L A E Y Q R W Q R Q A S K V V S Q R I S T V D L S C Y S L E E V P E H L F Y S Q D I T Y L N L R H N F M Q L E R P G G L D T L Y K F S Q L K G L N L S H N K L G L F P I L L C E I S T L T E L N L S C N G F H D L P S Q I G N L L N L Q T L C L D G N F L T T L P E E L G N L Q Q L S S L G I S F N N F S Q I P E V Y E K L T M L D R V V M A G N C L E V L N L G V L N R M N H I K H V D L R M N H L K T M V I E N L E G N K H I T H V D L R D N R L T D L D L S S L C S L E Q L H C G R N Q L R E L T L S G F S L R T L Y A S S N R L T A V N V Y P V P S L L T F L D L S R N L L E C V P D W A C E A K K I E V L D V S Y N L L T E V P V R I L S S L S L R K L M L G H N H V Q N L P T L V E H I P L E V L D L Q H N A L T R L P D T L F S K A L N L R Y L N A S A N S L E S L P S A C T G E E S L S M L Q L L Y L T N N L L T D Q C I P V L V G H L H L R I L H L A N N Q L Q T F P A S K L N K L E Q L E E L N L S G N K L K T I P T T I A N C K R L H T L V A H S N N I S I F P E I L Q L P Q I Q F V D L S C N D L T E I L I P E A L P A T L Q D L D L T G N T N L V L E H K T L D I F S H I T T L K I D Q K P L P T T D S T V T S T F W S H G L A E M A G Q R N K L C V S A L A M D S F A E G V G A V Y G M F D G D R N E E L P R L L Q C T M A D V L L E E V Q Q S T N D T V F M A N T F L V S H R K L G M A G Q K L G S S A L L C Y I R P D T A D P A S S F S L T V A N V G T C Q A V L C R G G K P V P L S K V F S L E Q D P E E A Q R V K D Q K A I I T E D N K V N G V T C C T R M L G C T Y L Y P W I L P K P H I S S T P L T I Q D E L L I L G N K A L W E H L S Y T E A V N A V R H V Q D P L A A A K K L C T L A Q S Y G C Q D N V G A M V V Y L N I G E E G C T C E M N G L T L P G P V G F A S T T T I K D A P K P A T P S S S S G I A S E F S S E M S T S E V S S E V G S T A S D E H N A G G L D T A L L P R P E R R C S L H P T P T S G L F Q R Q P S S A T F S S N Q S D N G L D S D D D Q P V E G V I T N G S K V E V E V D I H C C R G R D L E N S P P L I E S S P T L C S E E H A R G S C F G I R R Q N S V N S G M L L P M S K D R M E L Q K S P S T S C L Y G K K L S N G S I V P L E D S L N L I E V A T E V P K R K T G Y F A A P T Q M E P E D Q F V V P H D L E E E V K E Q M K Q H Q D S R L E P E P H E E D R T E P P E E F D T A L
Cofactor	COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. Mn(2+) is inhibitory below pH 8 and activating above pH 8 (PubMed:24892992). {ECO:0000250, ECO:0000269|PubMed:24892992};
Active site	No current data
Pfam	PF13855 PF00481
InterPro	IPR001611 IPR003591 IPR032675 IPR036457 IPR001932