| Uniprot ID | Q81258 |
| Uniprot Name | POLG_HCVNZ |
| Taxonomy ID | 356415 |
| Sequence | M S T L P K P Q R K T K R N T I R R P Q D V K F P G G G Q I V G G V Y V L P R R G P R L G V R A T R K T S E R S Q P R G R R Q P I P K A R R S E G R S W A Q P G Y P W P L Y G N E G C G W A G W L L S P R G S R P S W G P N D P R R R S R N L G K V I D T L T C G F A D L M G Y I P L V G A P V G G V A R A L A H G V R A L E D G I N F A T G N L P G C S F S I F L L A L F S C L I H P A A S L E W R N T S G L Y V L T N D C S N S S I V Y E A D D V I L H T P G C V P C V Q D G N T S T C W T P V T P T V A V R Y V G A T T A S I R S H V D L L V G A A T M C S A L Y V G D M C G A V F L V G Q A F T F R P R R H Q T V Q T C N C S L Y P G H L S G H R M A W D M M M N W S P A V G M V V A H V L R L P Q T L F D I M A G A H W G I L A G L A Y Y S M Q G N W A K V A I I M V M F S G V D A H T Y T T G G T A S R H T Q A F A G L F D I G P Q Q K L Q L V N T N G S W H I N S T A L N C N E S I N T G F I A G L F Y Y H K F N S T G C P Q R L S S C K P I T F F R Q G W G P L T D A N I T G P S D D R P Y C W H Y A P R P C D I V P A S S V C G P V Y C F T P S P V V V G T T D A R G V P T Y T W G E N E K D V F L L K S Q R P P S G R W F G C S W M N S T G F L K T C G A P P C N I Y G G E G N P H N E S D L F C P T D C F R K H P E T T Y S R C G A G P W L T P R C M V D Y P Y R L W H Y P C T V D F R L F K V R M F V G G F E H R F T A A C N W T R G E R C D I E D R D R S E Q H P L L H S T T E L A I L P C S F T P M P A L S T G L I H L H Q N I V D V Q Y L Y G V G S G M V G W A L K W E F V I L V F L L L A D A R V C V A L W L M L M I S Q T E A A L E N L V T L N A V A A A G T H G I G W Y L V A F C A A W Y V R G K L V P L V T Y S L T G L W S L A L L V L L L P Q R A Y A W S G E D S A T L G A G V L V L F G F F T L S P W Y K H W I G R L M W W N Q Y T I C R C E S A L H V W V P P L L A R G S R D G V I L L T S L L Y P S L I F D I T K L L M A V L G P L Y L I Q A T I T T T P Y F V R A H V L V R L C M L V R S V I G G K Y F Q M I I L S I G R W F N T Y L Y D H L A P M Q H W A A A G L K D L A V A T E P V I F S P M E I K V I T W G A D T A A C G D I L C G L P V S A R L G R E V L L G P A D D Y R E M G W R L L A P I T A Y A Q Q T R G L L G T I V T S L T G R D K N V V T G E V Q V L S T A T Q T F L G T T V G G V I W T V Y H G A G S R T L A G A K H P A L Q M Y T N V D Q D L V G W P A P P G A K S L E P C A C G S S D L Y L V T R D A D V I P A R R R G D S T A S L L S P R P L A C L K G S S G G P V M C P S G H V A G I F R A A V C T R G V A K S L Q F I P V E T L S T Q A R S P S F S D N S T P P A V P Q S Y Q V G Y L H A P T G S G K S T K V P A A Y V A Q G Y N V L V L N P S V A A T L G F G S F M S R A Y G I D P N I R T G N R T V T T G A K L T Y S T Y G K F L A D G G C S G G A Y D V I I C D E C H A Q D A T S I L G I G T V L D Q A E T A G V R L T V L A T A T P P G S I T V P H S N I E E V A L G S E G E I P F Y G K A I P I A L L K G G R H L I F C H S K K K C D E I A S K L R G M G L N A V A Y Y R G L D V S V I P T T G D V V V C A T D A L M T G F T G D F D S V I D C N V A V E Q Y V D F S L D P T F S I E T R T A P Q D A V S R S Q R R G R T G R G R L G T Y R Y V A S G E R P S G M F D S V V L C E C Y D A G C S W Y D L Q P A E T T V R L R A Y L S T P G L P V C Q D H L D F W E S V F T G L T H I D A H F L S Q T K Q Q G L N F S Y L T A Y Q A T V C A R A Q A P P P S W D E M W K C L V R L K P T L H G P T P L L Y R L G P V Q N E T C L T H P I T K Y L M A C M S A D L E V T T S T W V L L G G V L A A L A A Y C L S V G C V V I V G H I E L E G K P A L V P D K E V L Y Q Q Y D E M E E C S Q A A P Y I E Q A Q V I A H Q F K E K I L G L L Q R A T Q Q Q A V I E P I V T T N W Q K L E A F W H K H M W N F V S G I Q Y L A G L S T L P G N P A V A S L M A F T A S V T S P L T T N Q T M F F N I L G G W V A T H L A G P Q S S S A F V V S G L A G A A I G G I G L G R V L L D I L A G Y G A G V S G A L V A F K I M G G E C P T A E D M V N L L P A I L S P G A L V V G V I C A A I L R R H V G P G E G A V Q W M N R L I A F A S R G N H V S P T H Y V P E S D A A A R V T A L L S S L T V T S L L R R L H Q W I N E D Y P S P C S D D W L R T I W D W V C S V L A D F K A W L S A K I M P A L P G L P F I S C Q K G Y K G V W R G D G V M S T R C P C G A A I T G H V K N G S M R L A G P R T C A N M W H G T F P I N E Y T T G P S T P C P S P N Y T R A L W R V A A N S Y V E V R R V G D F H Y I T G A T E D E L K C P C Q V P A A E F F T E V D G V R L H R Y A P P C K P L L R D D I T F M V G L H S Y T I G S Q L P C E P E P D V S V L T S M L R D P S H I T A E T A A R R L A R G S P P S E A S S S A S Q L S A P S L K A T C Q T H R P H P D A E L V D A N L L W R Q E M G S N I T R V E S E T K V V V L D S F E P L R A E T D D V E P S V A A E C F K K P P K Y P P A L P I W A R P D Y N P P L L D R W K A P D Y V P P T V H G C A L P P R G A P P V P P P R R K R T I Q L D G S N V S A A L A A L A E K S F P S S K P Q E E N S S S S G V D T Q S S T T S K V P P S P G G E S D S E S C S S M P P L E G E P G D P D L S C D S W S T V S D S E E Q S V V C C S M S Y S W T G A L I T P C S A E E E K L P I S P L S N S L L R H H N L V Y S T S S R S A S Q R Q K K V T F D R L Q V L D D H Y K T A L K E V K E R A S R V K A R M L T I E E A C A L V P P H S A R S K F G Y S A K D V R S L S S R A I N Q I R S V W E D L L E D T T T P I P T T I M A K N E V F C V D P A K G G R K P A R L I V Y P D L G V R V C E K R A L Y D V I Q K L S I E T M G P A Y G F Q Y S P Q Q R V E R L L K M W T S K K T P L G F S Y D T R C F D S T V T E Q D I R V E E E I Y Q C C N L E P E A R K V I S S L T E R L Y C G G P M F N S K G A Q C G Y R R C R A S G V L P T S F G N T I T C Y I K A T A A A K A A N L R N P D F L V C G D D L V V V A E S D G V D E D R A A L R A F T E A M T R Y S A P P G D A P Q A T Y D L E L I T S C S S N V S V A R D D K G R R Y Y Y L T R D A T T P L A R A A W E T A R H T P V N S W L G N I I M Y A P T I W V R M V M M T H F F S I L Q S Q E I L D R P L D F E M Y G A T Y S V T P L D L P A I I E R L H G L S A F T L H S Y S P V E L N R V A G T L R K L G C P P L R A W R H R A R A V R A K L I A Q G G K A K I C G L Y L F N W A V R T K T N L T P L P A A G Q L D L S S W F T V G V G G N D I Y H S V S R A R T R H L L L C L L L L T V G V G I F L L P A R |
| Cofactor | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per NS3 protease domain. {ECO:0000250}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per NS5A N-terminal domain. {ECO:0000250}; |
| Active site | ACT_SITE 958 958 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 978 978 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 999 999 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 1089 1089 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1113 1113 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1171 1171 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}. |
| Pfam | PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998 |
| InterPro | IPR011492 IPR002521 IPR002522 IPR002519 IPR002531 IPR002518 IPR042205 IPR042209 IPR000745 IPR001490 IPR002868 IPR013193 IPR038568 IPR024350 IPR014001 IPR001650 IPR013192 IPR038170 IPR027417 IPR009003 IPR004109 IPR007094 IPR002166 |