| Uniprot ID | Q81487 |
| Uniprot Name | POLG_HCVTR |
| Taxonomy ID | 357355 |
| Sequence | M S T L P K P K R Q T K R N T L R R P K N V K F P A G G Q I V G E V Y V L P R R G P Q L G V R E V R K T S E R S Q P R G R R Q P T P K A R P R E G R S W A Q P G Y P W P L Y G N E G C G W A G W L L P P R G S R P S W G Q N D P R R R S R N L G K V I D T L T C G F A D L M G Y I P L I G A P V G G V A R A L A H G V R A L E D G V N Y A T G N L P G C S F S I F L L A L F S C L T C P A S S L E Y R N A S G L Y L L T N D C S N R S I V Y E A D D V I L H L P G C V P C V E T D N N N T S C W T P I S P T V A V K H P G V T T A S I R N H V N M L V A P P T L C S A L Y V E D A F G A V S L V G Q A F T F R P R Q H K T V Q T C N C S I Y P G H V S G H R M A W D M M M N W S P A I G L V I S H L M R L P Q T F F D L V V G A H W G V M A G L A Y F S M Q G N W A K V V I V L I M F S G V D A T T H T T G G S A A Q A T A G F T S F F T R G P S Q N L Q L V N S N G S W H I N S T A L N C N D S L N T G F I A G L F Y Y H K F N S S G C P E R M S S C K P I T Y F N Q G W G P L T D A N I N G P S E D R P Y C W H Y P P R P C N I T K P L N V C G P V Y C F T P S P V V V G T T D I K G L P T Y R F G V N E S D V F L L T S L R P P Q G R W F G C V W M N S T G F V K T C G A P P C N I Y G G M K D I E A N Q T H L K C P T D C F R K H H D A T F T R C G S G P W L T P R C L V D Y P Y R L W H Y P C T V N F S I F K V R M F V G G H E H R F S A A C N W T R G E R C D L E D R D R S E Q Q P L L H S T T D S L I L P C S F T P M R R L S T G L I H L H Q N I V D V Q Y L Y G V G S A V V G W A L K W E F V V L V F L L L A D A R V C V A L W M M L L I S Q A E A A M E N L V M L N A L S A A G Q Q G Y V W Y L V A F C A A W H I R G K L V P L I T Y G L T G L W P L A L L D L L L P Q R A Y A W T G E D D A T I G A G V L L L L G F F T L S P W Y K H W I G R L I W W N Q Y A I C R G E A A L Q V W V P P L L V R G S R D S V I L L A S L L Y P S L I F D I T K L L I A V L G P L Y L I Q A A L T S T P Y F V R A H V L I R I C M L V R S A M G G K Y V Q M A V L T V G R W F N T Y L Y D H L S P I Q D W A A E G L K G L A V A T E P V I F S P M E I K V I T W G A D T A A C G D I L C G L P V S A R L G R E L L L G P A D D Y K K M G W R L L S P I S A Y A Q Q T R G L F G T I V T S L T G R D K N V V T G E V Q V L S T A T Q T F L G T T V G G V M W T V Y H G A G S R T L A G N K R P A L Q M Y T N V D Q D L V G W P A P A G T K S L D P C T C G S S D L Y L V T R E A D V L P A R R R G D S T A S L L S T R P L S C L K G S S G G P V M C P S G H V V G I F R A A V C T R G V A K A L Q F I P V E T L S T Q V R S P S F S D N S T P P A V P E S Y Q V G Y L H A P T G S G K S T K V P A A Y V A Q G Y S V L V L N P S V A A T L G F G T Y M S K A Y G I D P N I R T G T R T I T T G A K L T Y S T Y G K F L A D G G C S G G A Y D V I I C D E C H A Q D A T S I L G I G T V L D Q A E T A G V R L T V L A T A T P P G S I T V P H P N I E E V G L T S D G E I P F Y G K A L P L A M I K G G R H L V F C H S K E K C D E L A S K L R G M G V N A V A F Y R G L D V S V I P V S G D V V V C A T D A L M T G Y T G D F D T V I D C N V A V E Q Y V D F S L D P T F S I E T R T V P Q D A V S R S Q R R G R T G R G R P G I Y R F V T P G E R P S G M F D S V V L C E C Y D A G C S W Y D L Q P A E T T V R L R A Y L S T P G L P V C Q D H L D F W E R V F T G L T H I D A H F L S Q A K Q Q G L N F A Y L V A Y Q A T V C A R A K A S P P C W D E M W K C L I R L K P T L Q G P T P L L Y R L G A I Q N D I C M T H P I T K Y I M A C M S A D L E V T T S A W V L V G G V L A A L A A Y C L S V G C V V I V G H I E L G G K P A L V P D R Q V L Y Q Q Y D E M E E C S Q S A P Y I E Q A Q A I A Q Q F K D K V L G L L Q R A S Q Q E A E I R P I V Q S Q W Q K A E A F W Q Q H M W N F V S G I Q Y L A G L S T L P G N P A V A S L M A F T A S V T S P L T T N Q T M F F N I L G G W V A T H L A G P A A S S A F V V S G L A G A A V G G I G I G R V L L D V L A G Y G A G V S G A L V A F K I M G G E L P T T E D M V N L L P A I L S P G A L V V G V I C A A V L R R H V G P G E G A V Q W M N R L I A F A S R G N H V S P T H Y V P E S D A A A K V T A L L S S L T V T R L L R R L H Q W I N E D Y P S P C N G D W L H D I W D W V C I V L S D F K T W L S A K I M P K V P G I P F L S C Q K G Y K G V W R G D G V M T T R C P C G E D F T G H V R N G S M R I A G S G L C A N M W H G T F P I N E Y T T G P S T P V P A H N Y S R A L W R V T S D S Y V E V R R V G D T H Y V V G A T N D G L K I P C Q V P A P E F F T E L D G V R L H R Y A P P C K P L L R D E I T F S V G L H S Y A N G S Q L S C E P E P D V A V L T S M L R D P A H I T A A T A A R R L A R G S P P S E A S S S A S Q L S A P S L K A T C Q T H R P H P D A E L I D A N L L W R Q E M G S N I T R V E S E T K V V I L D S F E P L R A E E D D T E L S I P A E C F K K P P K Y P P A L P I W A R P D Y N P P L L P S W K D P T Y E P P A V H G C A L P P T R P A P V P P P R R K R T I K L D G S N V S A A L L A L A E R S F P S T K P E G T G T S S S G V G T E S T A E S G D S P E T G E E S D V E S Y S S M P P L E G E P G D P D L D A D S W S T V S D S E E Q S V V C C S M S Y S W T G A I I T P C S A E E E K L P I S P L S N S L L R H H N L V Y S T S S R S A A A R Q K K V T F D R L Q V L D D H Y K N V L K E V K E R A S G V K G R L L S F E E A C S L V P P H S G R S K Y G Y S A K D V R S L S S K A M N Q I R S V W E D L L E D N S T P I P T T I M A K N E V F S V N P A K G G R K P A R L I V Y P D L G V R V C E K R A L Y D V I Q K L S I A T M G P A Y G F Q Y S P K Q R V E H L L K M W T S K K T P L G F S Y D T R C F D S T V T E H D I R T E E G I Y Q C C D L E P E A R K A I S A L T E R L Y I G G P M Y N S K G L Q C G Y R R C R A S G V L P T S F G N T I T C Y I K A T A A S R A A G L K N P S F L V C G D D L V V I S E S C G V E E D R T A L R A F T E A M T R Y S A P P G D A P Q P T Y D L E L I S S C S S N V S V A C D G A G K R Y Y Y L T R D P E T P L A R A A W E T A R H T P V N S W L G N I I M F A P T I W V R M V L I T H F F S I L Q A Q E Q L E R A L D F E M Y G A T Y S V T P L D L P A I I E R L H G L S A F S L H G Y S P T E L N R V A G A L R K L G I P P L R A W R H R A R A V R A K L I A Q G G K A R I C G L Y L F N W A V R T K T K L T P L P T A G Q L D L S S W F T V G V G G N D I Y H S V S R A R T R H L L L C L L L L T V G V G I F L L P A R |
| Cofactor | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per NS3 protease domain. {ECO:0000250}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per NS5A N-terminal domain. {ECO:0000250}; |
| Active site | ACT_SITE 960 960 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 980 980 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 1001 1001 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 1091 1091 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1115 1115 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1173 1173 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}. |
| Pfam | PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998 |
| InterPro | IPR011492 IPR002521 IPR002522 IPR002519 IPR002531 IPR002518 IPR042205 IPR042209 IPR000745 IPR001490 IPR002868 IPR013193 IPR038568 IPR024350 IPR014001 IPR001650 IPR013192 IPR038170 IPR027417 IPR009003 IPR004109 IPR007094 IPR002166 |