Uniprot ID	Q86924
Uniprot Name	POLN_AURAV
Taxonomy ID	44158
Sequence	M E K P T V H V D V D P Q S P F V L Q L Q K S F P Q F E I V A Q Q V T P N D H A N A R A F S H L A S K L I E H E I P T S V T I L D I G S A P A R R M Y S E H K Y H C V C P M R S P E D P D R L M N Y A S R L A D K A G E I T N K R L H D K L A D L K S V L E S P D A E T G T I C F H N D V I C R T T A E V S V M Q N V Y I N A P S T I Y H Q A L K G V R K L Y W I G F D T T Q F M F S S M A G S Y P S Y N T N W A D E R V L E A R N I G L C S T K L R E G T M G K L S T F R K K A L K P G T N V Y F S V G S T L Y P E N R A D L Q S W H L P S V F H L K G K Q S F T C R C D T A V N C E G Y V V K K I T I S P G I T G R V N R Y T V T N N S E G F L L C K I T D T V K G E R V S F P V C T Y I P P S I C D Q M T G I L A T D I Q P E D A Q K L L V G L N Q R I V V N G K T N R N T N T M Q N Y L L P A V A T G L S K W A K E R K A D C S D E K P L N V R E R K L A F G C L W A F K T K K I H S F Y R P P G T Q T I V K V A A E F S A F P M S S V W T T S L P M S L R Q K V K L L L V K K T N K P V V T I T D T A V K N A Q E A Y N E A V E T A E A E E K A K A L P P L K P T A P P V A E D V K C E V T D L V D D A G A A L V E T P R G K I K I I P Q E G D V R I G S Y T V I S P A A V L R N Q Q L E P I H E L A E Q V K I I T H G G R T G R Y S V E P Y D A K V L L P T G C P M S W Q H F A A L S E S A T L V Y N E R E F L N R K L H H I A T K G A A K N T E E E Q Y K V C K A K D T D H E Y V Y D V D A R K C V K R E H A Q G L V L V G E L T N P P Y H E L A Y E G L R T R P A A P Y H I E T L G V I G T P G S G K S A I I K S T V T L K D L V T S G K K E N C K E I E N D V Q K M R G M T I A T R T V D S V L L N G W K K A V D V L Y V D E A F A C H A G T L M A L I A I V K P R R K V V L C G D P K Q W P F F N L M Q L K V N F N N P E R D L C T S T H Y K Y I S R R C T Q P V T A I V S T L H Y D G K M R T T N P C K R A I E I D V N G S T K P K K G D I V L T C F R G W V K Q G Q I D Y P G P G G H D R A A S Q G L T R R G V Y A V R Q K V N E N P L Y A E K S E H V N V L L T R T E D R I V W K T L Q G D P W I K Y L T N V P K G N F T A T L E E W Q A E H E D I M K A I N S T S T V S D P F A S K V N T C W A K A I I P I L R T A G I E L T F E Q W E D L F P Q F R N D Q P Y S V M Y A L D V I C T K M F G M D L S S G I F S R P E I P L T F H P A D V G R V R A H W D N S P G G Q K F G Y N K A V I P T C K K Y P V Y L R A G K G D Q I L P I Y G R V S V P S A R N N L V P L N R N L P H S L T A S L Q K K E A A P L H K F L N Q L P G H S M L L V S K E T C Y C V S K R I T W V A P L G V R G A D H N H D L H F G F P P L S R Y D L V V V N M G Q P Y R F H H Y Q Q C E E H A G L M R T L A R S A L N C L K P G G T L A L K A Y G F A D S N S E D V V L S L A R K F V R A S A V R P S C T Q F N T E M F F V F R Q L D N D R E R Q F T Q H H L N L A V S N I F D N Y K D G S G A A P S Y R V K R M N I A D C T E E A V V N A A N A R G K P G D G V C R A I F K K W P K S F E N A T T E V E T A V M K P C H N K V V I H A V G P D F R K Y T L E E A T K L L Q N A Y H D V A K I V N E K G I S S V A I P L L S T G I Y A A G A D R L D L S L R C L F T A L D R T D A D V T I Y C L D K K W E Q R I A D A I R M R E Q V T E L K D P D I E I D E G L T R V H P D S C L K D H I G Y S T Q Y G K L Y S Y F E G T K F H Q T A K D I A E I R A L F P D V Q A A N E Q I C L Y T L G E P M E S I R E K C P V E D S P A S A P P K T I P C L C M Y A M T A E R I C R V R S N S V T N I T V C S S F P L P K Y R I K N V Q K I Q C T K V V L F N P D V P P Y I P A R V Y I N K D E P P V T P H T D S P P D T C S S R L S L T P T L S N A E S D I V S L T F S E I D S E L S S L N E P A R H V M I S S F K L R Y T A I Q A L P Q K L S W M R E D R T P R Q P P P V P P P R P K R A A K L S R L A N Q L N E L R R H A T I S S V Q A E V H Y N S G F T P E A E L N E R G S I L R K P P P V P P L R P K Q T T N L S R L A N Q L S M P I T F G D F A E G E L D R L L T P S P T P T F G D F S Q E E M D R F F G N R Q Y X L T G V G G Y I F S S D T G P G H L Q Q K S V I Q N S T T E I L I E R S R L E K I H A P V L D L Q K E E M L K C R Y Q M S P T V A N K S R Y Q S R K V E N M K A V T T G R L L D G L K M Y V T P D V E A E C Y K Y T Y P K P M Y S A S V P D R F V S P E V A V A V C N N F F H E N Y P T V A S Y Q I T D E Y D A Y L D M V E G S V S C L D T A T F C P A K L R S F P K T H S Y L E P T L R S A V P S A F Q N T L Q N V L S A A T K R N C N V T Q M R E L P V L D S A V F N V E C F K K Y A C N T D Y W E E F K E K P I R I T T E C V T S Y V A R L K G P E A A A L F A K T H Q L V P L Q E V P M D R F V M D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L T A V L L P N I H T L F D M S A E D F D A I I A A N F S Y V H P V L E T D I G S F D K S Q D D S L A L T A L M I L E D L G V D D R L M D L I E C A F G E I T S V H L P T A T T F K F G A M M K S G M F L T L F V N T V L N V V I A S R V L E Q R L R D S K C A A F I G D D N I I H G V V S D K I M A D R C A T W M N M E V K I I D A V I G I K A P Y F C G G F I L E D Q V T H T A C R V S D P L K R L F K L G K P L P V D D E Q D H D R R R A L E D E T R A W F R V G I Q G E L L K A V E S R Y E V Q E V Q P V L L A L A T F S R S D K A F K A L R G S P R H L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1020 1020 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1097 1097 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR029063 IPR001788