Uniprot ID	Q8B912
Uniprot Name	RPOA_PRRSB
Taxonomy ID	300563
Sequence	M S G I L D R C T C T P N A R V F V A E G Q V Y C T R C L S A R S L L P L N L Q V P E L G V L G L F Y R P E E P L R W T L P R A F P T V E C S P T G A C W L S A I F P I A R M T S G N L N F Q Q R M V R V A G E I Y R A G Q L T P T V L K T I Q V Y E R G C R W Y P I V G P V P G V G V Y A N S L H V S D K P F P G A T H V L T N L P L P Q R P K P E D F C P F E C A M A D V Y D I G R G A V M Y V A G G K V S W A P R G G D E V K F E P V P K E L K L V A N R L H T S F P P H H V V D M S K F T F M T P G S G V S M R V E Y Q Y G C L P A D T V P E G N C W W R L F D L L P P E V Q N K E I R H A N Q F G Y Q T K H G V P G K Y L Q R R L Q V N G L R A V T D T H G P I V I Q Y F S V K E S W I R H L K P V E E P S L P G F E D L L R I R V E P N T S P L A G K N E K I F R F G S H K W Y G A G K R A R K A R S G A T T M V A H R A S S A H E T R Q A T K H E G A G A N K A E H L K L Y S P P A E G N C G W H C I S A I V N R M V N S N F E T T L P E R V R P P D D W A T D E D L V N T I Q I L R L P A A L D R N G A C G G A K Y V L K L E G E H W T V S V N P G M S P S L L P L E C V Q G C C E H K G G L G S P D A V E V S G F D P A C L D R L L Q V M H L P S S T I P A A L A E L S D D S N R P V S P A A A T W T V S Q S Y A R H R G G N H H D Q V C L G K I I S L C Q V I E D C C C H Q N K T N R A T P E E V A A K I D Q Y L R G A T S L E E C L A K L E R V S P P G A A D T S F D W N V V L P G V E A A H Q T T E Q L H V N P C R T L V P P V T Q E P L G K D S V P L T A F S L S N C Y Y P A Q G N E V R H R E R L N S V L S K L E E V V L E E Y G L M S T G L G P R P V L P S G L D E L K D Q M E E D L L K L A N T Q A T S E M M A W A A E Q V D L K A W V K S Y P R W T P P P P P P R V Q P R K T K S V K S L P E D K P V P A P R R K V R S G C G S P V L M G D N V P N G S E D L T V G G P L N F P T P S E P M T P M S E P V L T P A L Q R V P K L M T P L D G S A P V P A P R R T V S R P M T P L S E P I F L S A P R H K F Q Q V E E A N P A T T T L T H Q N E P L D L S A S S Q T E Y E A S P L A S S Q N M S I L E A G G Q E A E E V L S E I S D I L N D T S P A P V S S S S S L S S V K I T R P K Y S A Q A I I D S G G P C S G H L Q K E K E A C L S I M R E A C D A S K L S D P A T Q E W L S R M W D R V D M L T W R N T S A Y Q A F R T L N G R F E F L P K M I L E T P P P H P C G F V M L P H T P A P S V S A E S D L T I G S V A T E D V P R I L G K I G D T G E L L N Q G P S A P F K G G P V C D Q P A K N S R M S P R E S D E S I I A P P A D T G G A G S F T D L P S S D S V D A N G G G P L R T V K T K A G R L L D Q L S C Q V F S L V S H L P V F F S H L F K S D S G Y S P G D W G F A A F T L F C L F L C Y S Y P F F G F A P L L G V F S G S S R R V R M G V F G C W L A F A V G L F K P V S D P V G T A C E F D S P E C R N V L H S F E L L K P W D P V R S L V V G P V G L G L A I L G R L L G G A R Y V W H F L L R F G I V A D C I L A G A Y V L S Q G R C K K C W G S C V R T A P N E I A F N V F P F T R A T R S S L I D L C D R F C A P K G M D P I F L A T V W R G C W T G R S P I E Q P S E K P I A F A Q L D E K R I T A R T V V A Q P Y D P N Q A V K C L R V L Q A G G A M V A E A V P K V V K V S A I P F R A P F F P A G V K V D P E C R I V V D P D T F T T A L R S G Y S T T N L V L G M G D F A Q L N G L K I R Q I S K P S G G G S H L V A A L H V A C S M A L H M L A G V Y V T A V G S C G T G T N D P W C T N P F A A P G Y G P G S L C T S R L C I S Q H G L T L P L T A L V A G F G L Q E I A L V V L I F V S M G G M A H R L S C K A D M L C I L L A I A S Y V W V P L T W L L C V F P C W L R W F S L H P L T I L W L V F F L I S V N I P S G I L A V V L L V S L W L L G R Y T N I A G L V T P Y D I H H Y T S G P R G V A A L A T A P D G T Y L A A V R R A A L T G R T M L F T P S Q L G S L L E G A F R T Q K P S L N T V N V V G S S M G S G G V F T I D G K I K C V T A A H V L T G N S A R V S G V G F N Q M L D F D V K G D F A I A D C P N W Q G A A P K A Q F C E D G W T G R A Y W L T S S G V E P G V I G N G F A F C F T A C G D S G S P V I T E A G E L V G V H T G S N K Q G G G I V T R P S G Q F C N V T P I K L S E L S E F F A G P K V P L G D V K I G S H I I K D T C E V P S D L C A L L A A K P E L E G G L S T V Q L L C V F F L L W R M M G H A W T P L V A V G F F I L N E I L P A V L V R S V F S F G M F V L S W L T P W S A Q V L M I R L L T A A L N R N R L S L G F Y S L G A V T S F V A D L A V T Q G H P L Q V V M N L S T Y A F L P R M M V V T S P V P V I A C G V V H L L A I I L Y L F K Y R C L H Y V L V G D G V F S S A F F L R Y F A E G K L R E G V S Q S C G M S H E S L T G A L A M R L T D E D L D F L T K W T D F K C F V S A S N M R N A A G Q F I E A A Y A K A L R I E L A Q L V Q V D K V R G T L A K L E A F A D T V A P Q L S P G D I V V A L G H T P V G S I F D L K V G S T K H T L Q A I E T R V L A G S K M T V A R V V D P T P A P P P V P V P I P L P P K V L E N G P N A W G D E D R L N K K K R R R M E A V G I F V M D G K K Y Q K F W D K N S G D V F Y E E V H N S T D E W E C L R A G D P A D F D P E T G V Q C G H I T I E D R V Y N V F T S P S G R K F L V P A N P E N R R A Q W E A A K L S V E Q A L G M M N V D G E L T A K E L E K L K G I I D K L Q G L T K E Q C L N C L L A A S G L T R C G R G G L V V T E T A V K I V K F H N R T F T L G P V N L K V A S E V E L K D A V E H N Q H P V A R P V D G G V V L L R S A V P S L I D V L I S G A D A S P K L L A R H G P G N T G I D G T L W D F E A E A T K E E V A L S A Q I I Q A C D I R R G D A P E I G L P Y K L Y P V R G N P E R V K G V L Q N T R F G D I P Y K T P S D T G S P V H A A A C L T P N A T P V T D G R S V L A T T M P S G F E L Y V P T I P A S V L D Y L D S R P D C P K Q L T E H G C E D A A L R D L S K Y D L V T Q G F V L P G V L R L V R K Y L F A H V G K C P P V H R P S T Y P A K N S M A G I N G N R F P T K D I Q S V P E I D V L C A Q A V R E N W Q T V T P C T L K K Q Y C G K K K T R T I L G T N N F I A L A H R A A L S G V T Q G F M K K A F N S P I A L G K N K F K E L Q T P V L G R C L E A D L A S C D R S T P A I V R W F A A N L L Y E L A C A E E H L P S Y V L N C C H D L L V T Q S G A V T K R G G L S S G D P I T S V S N T I Y S L V I Y A Q H M V L S Y F K S G H P H G L L F L Q D Q L K F E D M L K V Q P L I V Y S D D L V L Y A E S P S M P N Y H W W V E H L N L M L G F Q T D P K K T A I T D S P T F L G C R I I N G R Q L V P N R D R I L A A L A Y H M K A S N V S E Y Y A S A A A I L M D S C A C L E Y D P E W F E E L V V G I A Q C A R K D G Y S F P G P P F F L S M W E K L R S N H E G K K S R M C G Y C M A P A P Y A T A C G L D V C V Y H T H F H Q H C P V I I W C G H P A G S G S C G E C E P P L G K G T S P L D E V L E Q V P Y K P P R T V I M H V E Q G L T P L D P G R Y Q T R R G L V S V R R G I R G N E V D L P D G D Y A S T A L L P T C K E I N M V A V A P N V L R S R F I I G P P G A G K T H W L L Q Q V Q D G D V I Y T P T H Q T M L D M I R A L G T C R F N V P A G T T L Q F P A P S R T G P W V R I L A G G W C P G K N S F L D E A A Y C N H L D V L R L L S K T T L T C L G D F K Q L H P V G F D S H C Y V F D I M P Q T Q L K T I W R F G Q N I C D A I Q P D Y R D K L V S M V N T T R V T Y V E K P V R Y G Q V L T P Y H R D R E D G A I T I D S S Q G A T F D V V T L H L P T K D S L N R Q R A L V A I T R A R H A I F V Y D P H R Q L Q S M F D L P A K G T P V N L A V H R D E Q L I V L D R N N K E I T V A Q A L G N G D K F R A T D K R V V D S L R A I C A D L E G S S S P L P K V A H N L G F Y F S P D L T Q F A K L P A E L A P H W P V V T T Q N N E R W P D R L V A S L R P I H K Y S R A C I G A G Y M V G P S V F L G T P G V V S Y Y L T K F V R G E A Q V L P E T V F S T G R I E V D C R E Y L D D R E R E V A E S L P H A F I G D V K G T T V G G C H H V T S K Y L P R F L P K E S V A V V G V S S P G E A A K A F C T L T D V Y L P D L E A Y L H P E T Q S K C W K V M L D F K E V R L M V W K G K T A Y F Q L E G R H F T W Y Q L A S Y T S Y I R V P V N S T V Y L D P C M G P A L C N R R V V G S T H W G A D L A V T P Y D Y G A K I I L S S A Y H G E M P P G Y K I L A C A E F S L D D P V R Y K H T W G F E S D T A Y L Y E F T G N G E D W E D Y N G A F R A R Q K G K I Y K A T A T S M K F H F P P G P V I E P T L G L N
Cofactor	No current data
Active site	ACT_SITE 76 76 For Nsp1-alpha papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00872}.; ACT_SITE 146 146 For Nsp1-alpha papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00872}.; ACT_SITE 270 270 For Nsp1-beta papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00873}.; ACT_SITE 339 339 For Nsp1-beta papain-like cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00873}.; ACT_SITE 437 437 For Nsp2 cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00871}.; ACT_SITE 506 506 For Nsp2 cysteine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00871}.; ACT_SITE 1848 1848 Charge relay system; for 3C-like serine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00826}.; ACT_SITE 1873 1873 Charge relay system; for 3C-like serine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00826}.; ACT_SITE 1927 1927 Charge relay system; for 3C-like serine proteinase activity. {ECO:0000255|PROSITE-ProRule:PRU00826}.
Pfam	PF16749 PF14757 PF14756 PF05410 PF05411 PF05412 PF05579 PF00680 PF01443
InterPro	IPR027351 IPR031932 IPR038451 IPR008743 IPR023338 IPR008741 IPR038155 IPR025773 IPR038154 IPR027355 IPR023183 IPR008760 IPR037227 IPR032855 IPR027417 IPR032785 IPR009003 IPR001205 IPR007094