Uniprot ID	Q8IRU4
Uniprot Name	PDE4E_DROME
Taxonomy ID	7227
Sequence	M L N K N S A S S Q S L P R V H S F F N M I P S I M Q D D L A L T I L N D R D N M F S I K S Q R S H G E D L I V T P F A Q I L A S L R S V R N N L L S L T N V P A S N K S R R P N Q S S S A S R S G N P P G A P L S Q G E E A Y T R L A T D T I E E L D W C L D Q L E T I Q T H R S V S D M A S L K F K R M L N K E L S H F S E S S R S G N Q I S E Y I C S T F L D K Q Q E F D L P S L R V E D N P E L V A A N A A A G Q Q S A G Q Y A R S R S P R G P P M S Q I S G V K R P L S H T N S F T G E R L P T F G V E T P R E N E L G T L L G E L D T W G I Q I F S I G E F S V N R P L T C V A Y T I F Q S R E L L T S L M I P P K T F L N F M S T L E D H Y V K D N P F H N S L H A A D V T Q S T N V L L N T P A L E G V F T P L E V G G A L F A A C I H D V D H P G L T N Q F L V N S S S E L A L M Y N D E S V L E N H H L A V A F K L L Q N Q G C D I F C N M Q K K Q R Q T L R K M V I D I V L S T D M S K H M S L L A D L K T M V E T K K V A G S G V L L L D N Y T D R I Q V L E N L V H C A D L S N P T K P L P L Y K R W V A L L M E E F F L Q G D K E R E S G M D I S P M C D R H N A T I E K S Q V G F I D Y I V H P L W E T W A D L V H P D A Q D I L D T L E E N R D Y Y Q S M I P P S P P P S G V D E N P Q E D R I R F Q V T L E E S D Q E N L A E L E E G D E S G G E S T T T G T T G T T A A S A L S G A G G G G G G G G G M A P R T G G C Q N Q P Q H G G M
Cofactor	COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000250}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000250};
Active site	ACT_SITE 324 324 Proton donor. {ECO:0000250}.
Pfam	PF18100 PF00233
InterPro	IPR003607 IPR040844 IPR023088 IPR002073 IPR036971 IPR023174