Uniprot ID	Q8QL53
Uniprot Name	POLN_SLDV
Taxonomy ID	78540
Sequence	M M L N L T A N P S A G T T V T V D L P A D H P A L N Q F K T A F P G F E V V A S N R S S N D H A A A R A F S H L A T K W I E R D I D G R Q V I V A D I G S A P A R R V G A P D N V T Y H S V C P R K C A E D P E R L A S Y A R K L V R A V E K G D G H L V S D R I T D L K D V L E N P D T S L E T T S I C L N D D V S C K V K A D I A V Y Q D V Y A V D A P S T I Y A Q A D K G T R V V Y W I G F E P F V F H T D A M A G S F P L Y D A N W S D S A V L A A K N L P L C Y S G L S E D S I K W R F R F R D K P L V P S G E I H Y S V G S T H Y V E D R D K L K S W H L P S T F H F V A P N K Y T C R C D T V V S C G G Y V V K K I T I C E G I V G R P A N E E L A T S Y H R D G V V V T K F S D T I N H E Q V S F P V V T Y I P A V I C D Q M T A M T A D P V K Y P D V V K L L V G L N Q R I V V N G T T V R N V N S M D N S L I P V F A R A L C S W A D E A R R D M E D E Q D M Y G V T S V T T W I C I C R A Y D K R Q Q H T F Y R R P K Q S S G I Y V P A K F T G S L R A S L S A T Y L N L P L K Q L L L N T L K R A I K P G D Q A L A D E T E A R A H D A A E V H E L T E E E G R Q Q A A N P S Y I A D V L G Q D D E E E V D D G M S N V D L G E E D G V G S T I I D C Q R G T V K V I T A F G D N T M G E Y L V L S P V T V L R T R K L A V L L G P L A E E V M Q Y V H K G R T G R Y A I E K N N L K V L I P T G V S L K T A H F Q A L T E S A T L T Y N D Y L F T C R T L D Q L A T R G S A K N T D E V Y Y K L V D A A K A K D E Y V Y E L S S K Q C V K K E D A T G T V L Q G D I C N P P Y H Q F A F E A L R K R P A H T H D V H T I G I Y G V P G A G K T A I I T T E V T T R D L V A S G K K E N C E D I K R C V L E R R G L K I A A R T V D S L L Y G A Y R G A V D T L Y V D E A Y A C H S G T L L A L I A A V R P T G K V V L C G D P K Q V G C V N Q L Q M R M H Y N H E I S D R V L R K N I S R R C T H T L T A I V S N L N Y E G R M K T T N P C K K P V L I D T T G S T K P D K E A L V L T C F R G W V K D L K I L Y P H N E L M T A A A S Q G L T R E K V Y A V R C R V T S N P L Y E P T S E H I T V L L T R T N D E L V W K T L P N D P L I P I L S K P P K G D Y S A T M E D W E D E H N G I L A A L R E A C V P R M N F A H G K R N T C W A V T S S R V L H E A G V L I T P E D F N R I F P A F R E D K P H S A L A A L D A V A A L V W G L D T S S G I L S G K G S F M R L E N S H W S N S N R G Y E Y G L N L D A L E G Y E I A N P R M I K A L K Q R R G R E C Y D I E T G K L V P M D P G R V Q V P I N R V V P H V L V D T S A A A K P G F L E N R L S V D R W D Q V H S F K T R A A V K F A E L T K R V S Y N S V L D L G A A R G G V T D Y C V K K G K T V T C V S E Q W D S K P R G A V V I T A D I N G P L N N L G I F D L V F C D A A G P R R Y H H Y A Q C E D H A R R S T S A C K H G V E R T A K G G V F I V K A Y G M A D R R T E R A V E C T A R Y F K S V S V E K P V S S R I T N V E V F F K F S G R C R P H A R S I A H L G P Q L T D I Y A R T R K A Y K M L A R G S V A D K V K V A E I L N S M V G A A P G Y R V L N K N I I T A E E E V L V N A A N S N G R P G D G V C G A L Y G A F G D A F P N G A I G A G N A V L V R G L E A T I I H A A G A D F R E V D E E T G A R Q L R A A Y R A A A T L V T A N G I T S A A I P L L S T H I F S N G R N R L E Q S F G A L V E A F D T T E C D V T I Y C L A N N M A A R I Q Q L I D D H A R E E F D E E V V V E E E E E H E A N A M C D T E T L S S F G D E T V W V P K H S T L A G R P G Y S A T Y G D R R S L F V G T K F H R A A V A M S S I E A A W P R T K E A N A K L I E Y I R G Q H L V D V L K S C P V N D I P V G R P P S S L P C G C I Y A M T P E R V T V L K Q R P Q E G F V V C S A F K L P L T N I Q D V T K V E C T V R A P A E E P R P V R Y L Q E R R P V Q A A A R Q P R P A I V A A S V A G T A T S R R T P A P G S V Q V R L L P P R D G T V S R S S R T S S Q S S V T S S A G P I M P V P R R A P V A P A A S L A G S V H S H S V R S A P A I L R A A S T G A R S V R S V Q S G L T G H R D D A V S V A G S V R Q P S G P P S S V S T P A A P R G L T R E Q F G A V R A R A R R D L E L E G S E H G S Q A S F R S G S L V V G S T A S S Y S Q R P D D Q D T G S E P S G R G A A V R T R R R G Q R D G P G G Y I F S S D Q G T A H L S Q H N T Q T N N T T E V L M R T S V L P S N D H G T P D L L A E M K K R L A Y Q M R P T Q K N K S R Y L S A K V H N M K H K I V Q C L Q R G A G H Y L R E Q H A L P L W K N T F P K P R Y S D A C V V K F E S V N T A I V A A N M F I G C N Y P T L S S F G V T D K Y D A Y L D M V D G L N C N L D T V T F E P A K V R S L P K K S K Y N Q P L I Q S Q V P G P M A S T L Q S I L M A A T K R N C N V T Q M R E L P T M D S A A M N V E A F K K F A C K D T D L W T E F A E K P V R L S P G Q I E E Y V F H L Q G A K A N V M H S R V E A A C P D L S E V A M D R F T L D M K R D V K V T P G T K H V E E R P K V Q V I Q A A D P M A T A Y L C A I H R E L V R R L K A V L K P S I H V L F D M S S E D F D A I V G H G M K L G D K V L E T D I S S F D K S Q D Q A M A V T A L M L L E D L G V E E D L L T L I E A S F G D I T S V H L P T G T R F Q F G S M M K S G L F L T L F V N T L L N I T I A A R V L R E Q L A D T R C A A F I G D D N V I T G V V S D D M M V A R C A S W L N M E V K I M E M E I G D R S P Y F C G G F L L L D T V T G T V S R V S D P V K R L M K M G K P A L N D P E T D V D R C R A L R E E V E S W Y R V G I Q W P L Q V A A A T R Y G V N H L P L A T M A M A T L A Q D L R S Y L G A R G E Y V S L Y A
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1043 1043 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1113 1113 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01728 PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR002877 IPR029063 IPR001788