Uniprot ID	Q8QZ73
Uniprot Name	POLN_MAYAB
Taxonomy ID	374990
Sequence	M S K V F V D I E A E S P F L K S L Q R A F P A F E V E A Q Q V T P N D H A N A R A F S H L A T K L I E Q E T E K D T L I L D I G S A P A R R M M S E H T Y H C V C P M R S A E D P E R L L Y Y A R K L A K A S G E V V D R N I A A K I D D L Q S V M A T P D N E S R T F C L H T D Q T C R T Q A E V A V Y Q D V Y A V H A P T S L Y F Q A M K G V R T A Y W I G F D T T P F M F D T M A G A Y P T Y A T N W A D E Q V L K A R N I G L C S A S L T E G H L G K L S I M R K K K M T P S D Q I M F S V G S T L Y I E S R R L L K S W H L P S V F H L K G R Q S Y T C R C D T I V S C E G Y V V K K I T M S P G V F G K T S G Y A V T H H A E G F L V C K T T D T I A G E R V S F P I C T Y V P S T I C D Q M T G I L A T E V T P E D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P V V S Q A F S K W A K E Y R L D Q E D E K N M G M R E R T L T C C C L W A F K T H K N H T M Y K K P D T Q T I V K V P S E F N S F V I P S L W S A G L S I G I R H R I R L L L Q S R R V E P L V P S M D V G E A R A A E R E A A E A K E A E D T L A A L P P L I P T A P V L D D I P E V D V E E L E F R A G A G V V E T P R N A L K V T P Q D R D T M V G S Y L V L S P Q T V L K S V K L Q A L H P L A E S V K I I T H K G R A G R Y Q V D A Y D G R V L L P T G A A I P V P D F Q A L S E S A T M V Y N E R E F I N R K L Y H I A V H G A A L N T D E E G Y E K V R A E S T D A E Y V Y D V D R K Q C V K R E E A E G L V M I G D L I N P P F H E F A Y E G L K R R P A A P Y K T T V V G V F G V P G S G K S G I I K S L V T R G D L V A S G K K E N C Q E I M L D V K R Y R D L D M T A K T V D S V L L N G V K Q T V D V L Y V D E A F A C H A G T L L A L I A T V R P R K K V V L C G D P K Q C G F F N L M Q L Q V N F N H N I C T E V D H K S I S R R C T L P I T A I V S T L H Y E G R M R T T N P Y N K P V I I D T T G Q T K P N R E D I V L T C F R G W V K Q L Q L D Y R G H E V M T A A A S Q G L T R K G V Y A V R M K V N E N P L Y A Q S S E H V N V L L T R T E G R L V W K T L S G D P W I K T L S N I P K G N F T A T L E D W Q R E H D T I M R A I T Q E A A P L D V F Q N K A K V C W A K C L V P V L E T A G I K L S A T D W S A I I L A F K E D R A Y S P E V A L N E I C T K I Y G V D L D S G L F S A P R V S L H Y T T N H W D N S P G G R M Y G F S V E A A N R L E Q Q H P F Y R G R W A S G Q V L V A E R K T Q P I D V T C N L I P F N R R L P H T L V T E Y H P I K G E R V E W L V N K I P G Y H V L L V S E Y N L I L P R R K V T W I A P P T V T G A D L T Y D L D L G L P P N A G R Y D L V F V N M H T P Y R L H H Y Q Q C V D H A M K L Q M L G G D A L Y L L K P G G S L L L S T Y A Y A D R T S E A V V T A L A R R F S S F R A V T V R C V T S N T E V F L L F T N F D N G R R T V T L H Q T N G K L S S I Y A G T V L Q A A G C A P A Y A V K R A D I A T A I E D A V V N A A N H R G Q V G D G V C R A V A R K W P Q A F R N A A T P V G T A K T V K C D E T Y I I H A V G P N F N N T S E A E G D R D L A A A Y R A V A A E I N R L S I S S V A I P L L S T G I F S A G K D R V H Q S L S H L L A A M D T T E A R V T I Y C R D K T W E Q K I K T V L Q N R S A T E L V S D E L Q F E V N L T R V H P D S S L V G R P G Y S T T D G T L Y S Y M E G T K F H Q A A L D M A E I T T L W P R V Q D A N E H I C L Y A L G E T M D N I R A R C P V E D S D S S T P P K T V P C L C R Y A M T P E R V T R L R M H H T K D F V V C S S F Q L P K Y R I P G V Q R V K C E K V M L F D A A P P A S V S P V Q Y L T N Q S E T T I S L S S F S I T S D S S S L S T F P D L E S A E E L D H D S Q S V R P A L N E P D D H Q P T P T A E L A T H P V P P P R P N R A R R L A A A R V Q V Q V E V H Q P P S N Q P T K P I P A P R T S L R P V P A P R R Y V P R P V V E L P W P L E T I D V E F G A P T E E E S D I T F G D F S A S E W E T I S N S S X L G R A G A Y I F S S D V G P G H L Q Q K S V R Q H D L E V P I M D R V I E E K V Y P P K L D E A K E K Q L L L K L Q M H A T D A N R S R Y Q S R K V E N M K A T I I D R L K Q G S A Y Y V S A A A D K A V T Y H V R Y A K P R Y S V P V M Q R L S S A T I A V A T C N E F L A R N Y P T V A S Y Q I T D E Y D A Y L D M V D G S E S C L D R A N F C P A K L R C Y P K H H A Y H M P Q I R S A V P S P F Q N T L Q N V L A A A T K R N C N V T Q M R E L P T L D S A V Y N V E C F R K Y A C N N E Y W E E F A K K P I R I T T E N L T T Y V T K L K G G K A A A L F A K T H N L V P L Q E V P M D R F I M D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L N A V L L P N I H T L F D M S A E D F D A I I S E H F K P G D H V L E T D I A S F D K S Q D D S L A L T G L M I L E D L G V D N Q L L D L I E A A F G Q I T S C H L P T G T R F K F G A M M K S G M F L T L F I N T V L N I T I A S R V L E A R L T N S A C A A F I G D D N V V H G V V S D K L M A D R C A T W V N M E V K I I D A V M C I K P P Y F C G G F L V Y D H V T R T A C R I A D P L K R L F K L G K P L P A D D C Q D E D R R R A L Y D E V K K W S R S G L G S E I E V A L A S R Y R L E G S Y N L L L A M S T F A H S M K N F S A L R G P V I H L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1014 1014 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1084 1084 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR029063 IPR001788