Uniprot ID	Q96AT9
Uniprot Name	RPE_HUMAN
Taxonomy ID	9606
Sequence	M A S G C K I G P S I L N S D L A N L G A E C L R M L D S G A D Y L H L D V M D G H F V P N I T F G H P V V E S L R K Q L G Q D P F F D M H M M V S K P E Q W V K P M A V A G A N Q Y T F H L E A T E N P G A L I K D I R E N G M K V G L A I K P G T S V E Y L A P W A N Q I D M A L V M T V E P G F G G Q K F M E D M M P K V H W L R T Q F P S L D I E V D G G V G P D T V H K C A E A G A N M I V S G S A I M R S E D P R S V I N L L R N V C S E A A Q K R S L D R
Cofactor	COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:20923965}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:20923965}; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20923965}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:20923965}; Note=Binds 1 divalent metal cation per subunit. Active with Fe(2+), and probably also with Mn(2+), Zn(2+) and Co(2+). {ECO:0000269|PubMed:20923965};
Active site	ACT_SITE 37 37 Proton acceptor. {ECO:0000244|PDB:3OVQ, ECO:0000244|PDB:3OVR, ECO:0000269|PubMed:20923965}.; ACT_SITE 175 175 Proton donor. {ECO:0000244|PDB:3OVQ, ECO:0000244|PDB:3OVR, ECO:0000269|PubMed:20923965}.
Pfam	PF00834
InterPro	IPR013785 IPR026019 IPR000056 IPR011060