Uniprot ID	Q99MX0
Uniprot Name	TKTL1_MOUSE
Taxonomy ID	10090
Sequence	M S E A E A S S G M A H N A G P D E K T L Q V L R D M A N R L R I R S I K A T N S S T T S Y L I P C S N A E I M S V L F F Y T M R Y K Q E D P E N P D N D R C I L S K G L P F V N V A T G W P G Q G L G A A C G M A Y T G K Y F D Q A S Y R V F C L L G D E E S T E G S V W E A F A F A S Y Y N L D N L M A I F D V N R I G H S S S M S V E H C I A I Y Q K R C E A F G W N T Y V V D G R D V K T L C H V F S Q A A Q V R G K P T A V V A K T F K A R G M P N V E D A E S W Y G R P M P K E R A D A I V K L I E S Q I Q T N K I L V P S P P I E D S P Q I N I M N I C M T S P P V Y V A D D K V S T Q R A C G L A L A K L G H E N D R V I V L G S D T K N C N F S D I F K K E H P E R F I Q C C I A E Q N M V N V A L G C S T R D R T I V F A Y S F A A F F T R A F D Q I R L G A I S Q I N I N L I G C H C G V S T G D D N P Y H M A L E D L A M F R A I P N C V V F Y P S D A V S T E H A V Y L A A N T K E M C F I R T S Q A E T A I I Y T T Q E T F Q I G Q A K V V R H S D N D K V I V I G A G V T L H E A L V A A A E L S K E D I S I R V I D L F T I K P L D I A T I I S N A K A T G G R I I T V E D H Y P E G G I G G A V C A A V S M E P N I V V H N L A V M D V P R S G R C N E A L D F S G I S S R H I I V A V K C I L M T
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250|UniProtKB:P23254}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250|UniProtKB:P23254};
Active site	ACT_SITE 339 339 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR033248 IPR005474