Uniprot ID	Q9D4D4
Uniprot Name	TKTL2_MOUSE
Taxonomy ID	10090
Sequence	M A L A R D A K L E S D T L Q V L Q D V A N R L R I H S I R A T C A C S S G H P T S C C S V A E I M A V L F F H T M R Y K Q A D P E H P D N D R F V L S K G H A A P I L Y A V W V E V G R I C E S D L L N L R K I H C D L E G H P T P R L S F V D V A T G S L G Q G L G A A C G M A Y T G K Y F D K A S Y R V F C L M G D G E S S E G S V W E A L A F A S H Y N L D N L V A I F D V N R L G Q S G T A P L E H C T A V Y E K R C Q A F G W N T Y V V D G H D V E A L C Q A F W K A A Q V K N K P T A L I A K T F K G R G I P N V E D A E N W H G K P M P K D R A D G I V K L I E N R I Q T N R N L T P K P P I E D S P R I S M S N T K M T S L P V Y K L G D M I A T R E A Y G L A L A K L G Q S N Q R V I V L D G D T K N S T F S E V F K K E H P E R F I E C F I A E Q N M V S V A L G C A T R G R T I A F V S T F A A F L T R A F D Q I R M G A I S Q T N I N F V G S H C G V S V G E D G P S Q M A L E D L A M F R S I P N C T V F Y P S D A V S T E H A V Y L A A N T K G M C F I R T T R P K T A V I Y T A E E N F V I G Q A K V I R Q S A V D K V T V I G A G V T L H E A L V A A E E L S Q Q G I F I R V I D L F T I K P L D A V T I I Q S A K A T G G Q I I T V E D H Y R E G G I G E A V C A A I S R E P D I V V R Q L A V T E V P R S G K P S E L L D M F G I S A R H I I A A V K D T V M K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 371 371 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR020826 IPR033248 IPR005474