Uniprot ID	Q9H0I9
Uniprot Name	TKTL2_HUMAN
Taxonomy ID	9606
Sequence	M M A N D A K P D V K T V Q V L R D T A N R L R I H S I R A T C A S G S G Q L T S C C S A A E V V S V L F F H T M K Y K Q T D P E H P D N D R F I L S R G H A A P I L Y A A W V E V G D I S E S D L L N L R K L H S D L E R H P T P R L P F V D V A T G S L G Q G L G T A C G M A Y T G K Y L D K A S Y R V F C L M G D G E S S E G S V W E A F A F A S H Y N L D N L V A V F D V N R L G Q S G P A P L E H G A D I Y Q N C C E A F G W N T Y L V D G H D V E A L C Q A F W Q A S Q V K N K P T A I V A K T F K G R G I P N I E D A E N W H G K P V P K E R A D A I V K L I E S Q I Q T N E N L I P K S P V E D S P Q I S I T D I K M T S P P A Y K V G D K I A T Q K T Y G L A L A K L G R A N E R V I V L S G D T M N S T F S E I F R K E H P E R F I E C I I A E Q N M V S V A L G C A T R G R T I A F A G A F A A F F T R A F D Q L R M G A I S Q A N I N L I G S H C G V S T G E D G V S Q M A L E D L A M F R S I P N C T V F Y P S D A I S T E H A I Y L A A N T K G M C F I R T S Q P E T A V I Y T P Q E N F E I G Q A K V V R H G V N D K V T V I G A G V T L H E A L E A A D H L S Q Q G I S V R V I D P F T I K P L D A A T I I S S A K A T G G R V I T V E D H Y R E G G I G E A V C A A V S R E P D I L V H Q L A V S G V P Q R G K T S E L L D M F G I S T R H I I A A V T L T L M K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 370 370 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR033248 IPR005474