Uniprot ID	Q9I7S6
Uniprot Name	PDE9A_DROME
Taxonomy ID	7227
Sequence	M Y Q D S G C S S S S S R R G S S S A A A A T S T A A T A A E T A A A A A A T T T S S S D E E T L E T L T I I T T T I T D S D I H A T T T T T T V I A S G T A T T A A A A A T T A T L A T L A T L A S N S D I E D S S P V E S E D S E E C E Y I E I D C Q T T A Q E G T S P S G G S S S S G N A V L L Q R S S N N L Q Q Q Q Q Q Q Q Q Q Q Q H L Q L Q L Q Q A D E R L L R K I G Y I A S R V R C L S K Y Y G D F R L V N P Y S A R R Q R R Q L Q E I L L R H S I F D P G K E H Q R A I V L A A A T A A I A G P L A A I D C V C G S S S I S L E A V S S R S R S S E L E D D H H E Q D Q V Q E E Q E Q E Q H Q G D T E D N E E E Q E H P S E K P E R T D I E E E P P P A I A V T T T T T A T V R R K S S S S S T I S G T A T V S G S V S V S A S A S Q S F C S N N I N L L E E L L I Q F Y E E Q D H R S N L T V I R H H H H Q Q H Q Q H Q Q Q Q R I T N N N N N N N N C N S I Q N N N N M S N P A A T A A A T A T P S V E Q P A T S G T T N I H L Q P T S L P D G S D N P R R R R A S D C S A V Q A A L Q N Q L H C I T L K N N N C G K A M P F H R G S C G A A G E H L L A A N S I A N R A T I I L S K S C S N V D G D A T A T A A T A L S S T V G G G I G G I G G S I K M R A S A T D I E T N A L N G A R D A I V A S N N G N N G N N G N N G N N E Y S I L Q L N N T I I Q C H F N D D D F R A L V K D L K R K V E Y T E R M N W L C L S K R P L G P P H R K S S L P K H Q E V K R R F L E I C D T T F S E E V R A A L R L P A F D S Y E W S D A D V I H L M Q T M F V E L G F I E K F S I P V D T L R E W L Y E V Y K H Y N E V P F H N F R H C F C V A Q M M Y A I T R Q A N L L S R L G D L E C L I L L V S C I C H D L D H P G Y N N I Y Q I N A R T E L A L R Y N D I S P L E N H H C S I A F R L L E H P E C N I F K N F S R D T F N N I R E G I I R C I L A T D M A R H N E I L T Q F M E I T P I F D Y S N R A H I N L L C M I L I K V A D I S N E A R P M D V A E P W L D R L L Q E F F A Q S A A E K S E G L P V T P F M D P D K V S K P G S Q V R F I G L V L L P L F E A L G E L V P E L T E L I I I P V R I A L E Y Y R R L N D A Q T K T R K S V A D S N T S A T S D S N S G T I D S N A A M V S T P G G A S D K L S L D K G Q G N S Q G S G G G G G G G G G G G A G G G T G S G C G S N A A G S V S P Q M P R S G S G I S V K S R R S I P S Q K S A S R T S V D E P G G M A S E L H D L P E G S E S G D S E T A T E V D V A E K T S K F K V D T E G S S N R S K S S H S T S R K S S R E K R P S M I G E L C S S G G G Q R I R N S Y G N I H G Y H S N R C H F G N N R A V S L D Q Y S S A G N N R R L S D G L P Q V I S D S N V F Y G R H N R S S T E T T V A V G N P Q D T N A N T N H P V G C Q L K E L L A R T E A D S D G E G D G N G R E D K K I P L V I P S M P Q L A T S S N G N I S P T L V V T E Q I L P S N G S T R S S A S S G R G G S G V P G G S G G S G M P G P S A G S G S S W K S R L R Q F S D Y F S F S F D K S N K R F G S T R S S P C P G S N S S S G R T N N N A N G L G E N Q D G L G A G G G I K P G M C C T T I T N S S G S T V K G E T R G G T A G A G G G A L T T M T T G N D A H Q R H R A Y S L D V P G M M R Y S S N D S S R H P S N N T L Q S A G G G A G L T T G L E V T A Q R V P P S L S V E M G L A S G S S S E A G P K I
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:O76083}; Note=Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc. {ECO:0000250|UniProtKB:O76083}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:O76083}; Note=Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc. {ECO:0000250|UniProtKB:O76083};
Active site	ACT_SITE 740 740 Proton donor. {ECO:0000250|UniProtKB:O76083}.
Pfam	PF00233
InterPro	IPR003607 IPR023088 IPR002073 IPR036971 IPR023174