Uniprot ID	Q9NVH0
Uniprot Name	EXD2_HUMAN
Taxonomy ID	9606
Sequence	M S R Q N L V A L T V T T L L G V A V G G F V L W K G I Q R R R R S K T S P V T Q Q P Q Q K V L G S R E L P P P E D D Q L H S S A P R S S W K E R I L K A K V V T V S Q E A E W D Q I E P L L R S E L E D F P V L G I D C E W V N L E G K A S P L S L L Q M A S P S G L C V L V R L P K L I C G G K T L P R T L L D I L A D G T I L K V G V G C S E D A S K L L Q D Y G L V V R G C L D L R Y L A M R Q R N N L L C N G L S L K S L A E T V L N F P L D K S L L L R C S N W D A E T L T E D Q V I Y A A R D A Q I S V A L F L H L L G Y P F S R N S P G E K N D D H S S W R K V L E K C Q G V V D I P F R S K G M S R L G E E V N G E A T E S Q Q K P R N K K S K M D G M V P G N H Q G R D P R K H K R K P L G V G Y S A R K S P L Y D N C F L H A P D G Q P L C T C D R R K A Q W Y L D K G I G E L V S E E P F V V K L R F E P A G R P E S P G D Y Y L M V K E N L C V V C G K R D S Y I R K N V I P H E Y R K H F P I E M K D H N S H D V L L L C T S C H A I S N Y Y D N H L K Q Q L A K E F Q A P I G S E E G L R L L E D P E R R Q V R S G A R A L L N A E S L P T Q R K E E L L Q A L R E F Y N T D V V T E E M L Q E A A S L E T R I S N E N Y V P H G L K V V Q C H S Q G G L R S L M Q L E S R W R Q H F L D S M Q P K H L P Q Q W S V D H N H Q K L L R K F G E D L P I Q L S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:29335528, ECO:0000269|PubMed:31127291}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:29335528, ECO:0000269|PubMed:31127291}; Note=Divalent metal cations; Mg(2+) or Mn(2+) (PubMed:31127291). Acts as a 3'-5' exoribonuclease in presence of Mg(2+), while it has no 3'-5' exodeoxyribonuclease activity (PubMed:29335528, PubMed:31127291). Has both as a 3'-5' exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:31127291). {ECO:0000269|PubMed:29335528, ECO:0000269|PubMed:31127291};
Active site	No current data
Pfam	PF01612
InterPro	IPR002562 IPR012337 IPR036397