Uniprot ID	Q9QAX1
Uniprot Name	POLG_HCVVA
Taxonomy ID	356414
Sequence	M S T N P K P Q R K T K R N T N R R P Q D V K F P G G G Q I V G G V Y L L P R R G P R L G V R A T R K T S E R S Q P R G R R Q P I P K D R R S A G K S W G R P G Y P W P L Y G N E G L G W A G W L L S P R G S R P S W G P T D P R H R S R N L G K V I D T L T C G F A D L M G Y I P V V G A P V G G V A R A L A H G V R V L E D G I N Y A T G N L P G C S F S I F L L A L L S C M S V P V S A V E V K N T S Q I Y M A T N D C S N N S I T W Q L E G A V L H V P G C V P C E S T G N I S R C W I P V T P N V A V R E R G A L T K G L R T H I D L I V V S A T F C S A L Y I G D V C G A I M I A A Q A T I I S P Q H H T F V Q D C N C S I Y P G H V T G H R M A W D M M M N W S P A T T M I M A Y F M R V P E V V L D I I T G A H W G V M F G L A Y F S M Q G A W A K V V V I L L L T A G V D A Q T H T I S G H A A R T T H G L V S L F T P G S Q Q N I Q L V N T N G S W H I N R T A L N C N D S L K T G F I A A L F Y S H K F N S S G C P Q R M S S C R S I E E F R I G W G N L E Y E E N V T N D D N M R P Y C W H Y P P R P C G I V P A Q T V C G P V Y C F T P S P V V V G T T D R R G V P T Y T W G E N D T D V F L L N S T R P P R G A W F G C T W M N S T G F T K T C G A P P C R I R P D F N S S E D L L C P T D C F R K H S E A T Y T R C G A G P W L T P K C L F H Y P Y R L W H Y P C T I N F T I H K I R M F I G G V E H R L E A A C N F T R G D R C N L E D R D R S Q L S P L L H S T T E W A I L P C T F S D M P A L S T G L L H L H Q N I V D V Q Y L Y G L S P A I T K Y I V K W E W V V L L F L L L A D A R V C A C L W M L L L L G Q A E A A L E K L V I L H A A S A A S S H G M L C F I I F F I A A W Y I K G R V T P L V T Y S Y L G M W S F S L L L L A L P Q Q A Y A L D T T E Q G Q I G L V L L V V I S V F T L S P A Y K I L L C R S L W W L S Y L L V R A E A L I Q D W V P P W Q A R G G R D G I I W A A T I F C P G V L F D I T N W L L A I L G P G Y L L R S V L T S T P Y F V R A Q A L L R I C A A V R H L S G G K Y V Q M M L L T L G K W T G T Y I Y D H L S P M S G W A A S G L R D L A V A V E P I V F S P M E K K V I V W G A E T A A C G D I L H G L P V S A R L G Q E V L L G P A D E Y T S K G W K L L A P I T A Y A Q Q T R G L L G T I V V S M T G R D K T E Q A G E I Q V L S T V T Q S F L G T T I S G I L W T V F H G A G N K T L A G S R G P V T Q M Y S S A E G D L V G W P S P P G T R S L D P C T C G A V D L Y L V T R N A D V I P A R R Q G D R R G A L L S P R P L S S L K G S S G G P V L C P R G H A V G I F R A A I C T R G A A K S I D F I P I E S L D V I I R S P N F T D N S S P P A V P Q T Y Q V G Y L H A P T G S G K S T K V P A S Y A A Q G Y K V L V L N P S V A A T L G F G A Y M S K A H G I N P N I R T G V R T V T T G E S I T Y S T Y G K F L A D G G C S G G A Y D V I I C D E C H S V D A T T I L G I G T V L D Q A E T A G A R L T V L A T A T P P G S V T T P H P N I E E V A L G H E G E I P F Y G K A I P L S Q I K G G R H L I F C H S K K K C D E L A A A L R G M G L N A V A Y Y R G L D V S V I P T Q G D V V V V A T D A L M T G F T G D F D S V V D C N V A V T Q T V D F S L D P T F T V T T Q T V P Q D A V S R S Q R R G R T G R G R L G I Y R Y V S S G E R A S G M F D S V V L C E C Y D A G A A W Y E L T P A E T T V R L R A Y F N T P G L P V C Q D H L E F W E A V F T G L T H I D A H F L S Q T K Q A G E N F P Y L V A Y Q A T V C A R A K A P P P S W D V M W K C L I R L K P T L T G P T P L L Y R L G P V T N E T T L T H P V T K Y I A T C M Q A D L E I M T S T W V L A G G V L A A I A A Y C L A T G C V V C I G R V N I N Q K T I V A P D K E V L Y E A F D E M E E C A S R A L L L E E G Q R I A E M L K S K I Q G L L Q Q A T K Q A Q D I Q P A V Q A T W P K L E Q F W A K H M W N F I S G I Q Y L A G L S T L P G N P A V A A M M A F S A A L T S P L P T S T T I L L N I M G G W L A S Q I A P A A G A T G F V V S G L V G A A V G S I G L G K I L V D V L A G Y G A G I S G A L V A F K I M S G E K P S V E D V V N L L P G I L S P G A L V V G V I C A A I L R R H V G Q G E G A V Q W M N R L I A F A S R G N H V A P T H Y V A E S D A S Q R V T Q L L G S L T I T S L L R R L H T W I T E D C P V P C A G S W L R D I W D W A C T I L T D F K N W L S T K L L P K M P G L P F I S C Q R G H K G A W T G T G I M T T R C P C G A V V S G N V R H G S M R I T G P K T C M N T W Q G T F P I N C Y T E G Q C A P Q P T H N Y K T A I W K V A A A E Y A E V T R H G S Y A Y V T G L T N D N L K V P C Q L P A P E F F S W V D G V Q I H R F A P T P K P F I R D E V S F T V G L N S F V V G S Q L P C E P E P D T E V L A S M L T D P S H I T A E A A A R R L A R G S P P S E A S S S A S Q L S A P S L R A T C T A H A K N Y A V E M V D A N F F M G S D V T R I E S E T K V L I L D S L D P S V E E E D E R E P S V P S E Y L L P K K K F P Q A L P V W A R P D Y N P P V V E T W K R P D Y D P P T V S G C A L P P R V T A P T P P P R R R R A L V L S Q S N V G E A L Q A L A I K S F G Q L P P S C D S G R S T G M D T T D A T D Q P A L K E S T D S E A G S D S S M P P L E G E P G D P D L E S G S V E Y H P S S Q E G E A A P D L D S G S W S T C S E E G G S E V C C S M S Y S W T G A L I T P C G P E E E K L P I N P L S N S L L R Y H N K V Y S T T S R S A S Q R A K K V T F D R V Q L L D S H Y D Q V L K D I K L A A S K V S A N L L S I E E A C A L T P P H S A R S K Y G F G A K E V R S L S R K A V D H I K S V W K D L L E D Q Q T P I P T T I M A K N E V F C I D P T K G G K K A A R L I V F P D L G V R V C E K M A L Y D I T Q K L P Q A V M G A S Y G F Q Y S P A Q R V D F L L R A W K E K K D P M G F S Y D T R C F D S T V T E R D I R T E E S I Y L A C S L P E E A R V A I H S L T E R L Y V G G P M M N S K G Q S C G Y R R C R A S G V L T T S M G N T I T C Y V K A L A A C K A A G I V A P T M L V C G D D L V V I S E S Q G A E E D E R N L R V F T E A M T R Y S A P P G D P P K P E Y D L E L I T S C S S N V S V A L D Q H G R R M Y Y L T R D P S T P L A R A A W E T A R H S P V N S W L G N I I Q Y A P T I W V R M V L M T H F F S V L M A Q E T L D Q D L N F E M Y G A V Y S V N P L D L P A I I E R L H G L E A F S L H G Y S P T E L T R V A A A L R K L G A P P L R A W K S R A R A V R A S L I S Q G G R A A T C G F Y L F N W A V R T K R K L T P L P A A R R L D L S G W F T V G A G G G D I Y H S V S R A R P R F L L L C L L L L S V G V G I F L L P A R
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per NS3 protease domain. {ECO:0000250}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per NS5A N-terminal domain. {ECO:0000250};
Active site	ACT_SITE 956 956 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 976 976 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 997 997 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 1087 1087 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1111 1111 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1169 1169 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.
Pfam	PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998
InterPro	IPR011492 IPR002521 IPR002522 IPR002519 IPR002531 IPR002518 IPR042205 IPR042209 IPR000745 IPR001490 IPR002868 IPR013193 IPR038568 IPR024350 IPR014001 IPR001650 IPR013192 IPR038170 IPR027417 IPR009003 IPR004109 IPR007094 IPR002166