Uniprot ID	Q9QSK1
Uniprot Name	TOP2_IIV6
Taxonomy ID	176652
Sequence	M A T S N H K K Q Y T T L S D I D H V L L R P E V I I G S T V P M E Q T E Y V V D E N F S E I L E K Q V F V S E A L I R I F V E V L A N A V D N I H R S K G S S T P C K S I K I K I E D D G T T M I H N D G Q V I K I S K E E N D G I E I N G K K C S V Y N H E L V F G H L R S S S N Y D D T V V R Q T S G K N G L G V K C T N I L S K S F K V I G V D P E N K K K F V Q E W T N N M K E T S G P K V T T S S S K T G Y T E V I Y C P D F E R L G N F S S D I I G I F R K H V L D V A M L A S S E G V S V Y F N D K K L P I K K F S D Y T K L F K L E K E S I S I T E E D G S S E V T I A F V E R D G K K K P I S F V N G L F T K H G G Q H V D G W T K P F F A N L L S V L N K P S K T Y K D L K L S L K D V T P Y F R F F V K S T V D K P Q F D C Q N K N M L K S P C L K Y T I P D K I I T K V C K W T S V Q E L K Q S S F E K L L K G K D N N I I K T L N D K K R R P K V S V K E Y D P A N K A G T T L S E K C T L I V C E G L S A K T Y A V A G I S T G I S F T G T D T K K G R D W F G I L P L R G K F L N V R N A N N D K M I K N T V V T D L V N A M G L T F G M D Y S T Q K S R K S L N Y G S I I I I P D P D E D G I H I E G L V L N F F H H H F S S L F N P V V P N L K D F P F I S S M K I P I I K V I E K P L K G R R E I E F F T H E A F H K F K N E N K W H K N H E I K Y F K G L G T T K H E D V P K I F G K K M V V F N I D D N A H E N M E K A F K D E E A D E R K E W L K Q Y N P N A R T F D L D S P N K I L Q L N I S T F I N E E L I K F S I E D C K R S L P H L I D G L K E S Q R K V I F G L K Q W N G K N N I K V A Q L G A F V A Q K T D Y K H G E Q N L F D T I I K M A Q T F V G A N N I P L L E E D G Q F G T R L S G G K D A A S P R Y I F V N Q P P I L N K I F R P E D D P I L N Y T L D G E P V F Y A P V I P L I C I N G S V G V G T G F S C N I P M F N P S E I I D G L K Q W I N M R E Q G E K Y V F K Y K P W Y K G F T G K I E K N G S G R Y I S Y G T L S N E A S N N G M Y Q Y T V S E L P I N M W T D K F K E M C D Q Y R E S N L I K T C D N Y S E V T T V N F K I S S E H E L T I E N L K L R S Y I H T S N M V M F D H E G K I H K Y E T L N G I M Q R F C K E R I K I Y E K R R Q Y M L Q K L N K S L T I S E N K K R F M E D V M N Q K I K I L L Q E D E V V H Q Q L L D M N Y Y K D D E G E F D Y L L N M N I G G F R K K N V D K L I S K I D D L K K D I M W Y T N T N E G Q M W L K D I L E L E P F I
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 803 803 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF16898
InterPro	IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR031660 IPR006171