Uniprot ID	Q9UG56
Uniprot Name	PISD_HUMAN
Taxonomy ID	9606
Sequence	M A T S V G H R C L G L L H G V A P W R S S L H P C E I T A L S Q S L Q P L R K L P F R A F R T D A R K I H T A P A R T M F L L R P L P I L L V T G G G Y A G Y R Q Y E K Y R E R E L E K L G L E I P P K L A G H W E V A L Y K S V P T R L L S R A W G R L N Q V E L P H W L R R P V Y S L Y I W T F G V N M K E A A V E D L H H Y R N L S E F F R R K L K P Q A R P V C G L H S V I S P S D G R I L N F G Q V K N C E V E Q V K G V T Y S L E S F L G P R M C T E D L P F P P A A S C D S F K N Q L V T R E G N E L Y H C V I Y L A P G D Y H C F H S P T D W T V S H R R H F P G S L M S V N P G M A R W I K E L F C H N E R V V L T G D W K H G F F S L T A V G A T N V G S I R I Y F D R D L H T N S P R H S K G S Y N D F S F V T H T N R E G V P M R K G E H L G E F N L G S T I V L I F E A P K D F N F Q L K T G Q K I R F G E A L G S L
Cofactor	COFACTOR: Name=pyruvate; Xref=ChEBI:CHEBI:15361; Evidence={ECO:0000255|HAMAP-Rule:MF_03208}; Note=Binds 1 pyruvoyl group covalently per subunit. {ECO:0000255|HAMAP-Rule:MF_03208};
Active site	ACT_SITE 191 191 Charge relay system; for autoendoproteolytic cleavage activity. {ECO:0000255|HAMAP-Rule:MF_03208}.; ACT_SITE 267 267 Charge relay system; for autoendoproteolytic cleavage activity. {ECO:0000255|HAMAP-Rule:MF_03208}.; ACT_SITE 378 378 Charge relay system; for autoendoproteolytic cleavage activity. {ECO:0000255|HAMAP-Rule:MF_03208}.; ACT_SITE 378 378 Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity. {ECO:0000255|HAMAP-Rule:MF_03208}.
Pfam	PF02666
InterPro	IPR003817 IPR033177 IPR033661