Uniprot ID	Q9UNA4
Uniprot Name	POLI_HUMAN
Taxonomy ID	9606
Sequence	M E K L G V E P E E E G G G D D D E E D A E A W A M E L A D V G A A A S S Q G V H D Q V L P T P N A S S R V I V H V D L D C F Y A Q V E M I S N P E L K D K P L G V Q Q K Y L V V T C N Y E A R K L G V K K L M N V R D A K E K C P Q L V L V N G E D L T R Y R E M S Y K V T E L L E E F S P V V E R L G F D E N F V D L T E M V E K R L Q Q L Q S D E L S A V T V S G H V Y N N Q S I N L L D V L H I R L L V G S Q I A A E M R E A M Y N Q L G L T G C A G V A S N K L L A K L V S G V F K P N Q Q T V L L P E S C Q H L I H S L N H I K E I P G I G Y K T A K C L E A L G I N S V R D L Q T F S P K I L E K E L G I S V A Q R I Q K L S F G E D N S P V I L S G P P Q S F S E E D S F K K C S S E V E A K N K I E E L L A S L L N R V C Q D G R K P H T V R L I I R R Y S S E K H Y G R E S R Q C P I P S H V I Q K L G T G N Y D V M T P M V D I L M K L F R N M V N V K M P F H L T L L S V C F C N L K A L N T A K K G L I D Y Y L M P S L S T T S R S G K H S F K M K D T H M E D F P K D K E T N R D F L P S G R I E S T R T R E S P L D T T N F S K E K D I N E F P L C S L P E G V D Q E V F K Q L P V D I Q E E I L S G K S R E K F Q G K G S V S C P L H A S R G V L S F F S K K Q M Q D I P I N P R D H L S S S K Q V S S V S P C E P G T S G F N S S S S S Y M S S Q K D Y S Y Y L D N R L K D E R I S Q G P K E P Q G F H F T N S N P A V S A F H S F P N L Q S E Q L F S R N H T T D S H K Q T V A T D S H E G L T E N R E P D S V D E K I T F P S D I D P Q V F Y E L P E A V Q K E L L A E W K R A G S D F H I G H K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:27555320}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:27555320}; Note=Binds nucleotide much more tightly and catalyzes nucleotide insertion much more efficiently in the presence of Mg(2+) than in the presence of Mn(2+). {ECO:0000269|PubMed:27555320};
Active site	ACT_SITE 152 152 Proton acceptor. {ECO:0000255|PROSITE-ProRule:PRU00216}.
Pfam	PF00817 PF11799
InterPro	IPR036775 IPR017961 IPR001126