Uniprot ID	Q9Y8G8
Uniprot Name	TOP2_PENCH
Taxonomy ID	5076
Sequence	M S D A D P F D M S D D D D N S V L S H T P P K K Q K K A P T T K K G G S K P L A D V E N E S F M D G I E E S N N Q D K D T N V S E K Y Q K L T Q L E H I I K R P D T Y V G S T E R T T Q H M W V Y S S E S E G M E Y R E V S Y V P G L Y K I F D E I V V N A A D N K Q N D K N M D E I R V T I D R E S G E I S V W N N G R G I P I E M H S K E K M Y V P E L I F G H L L T S S N Y D D T Q M K V T G G R N G F G A K L C N V F S T E F T I E T Q D S R Q K K K Y K Q T W T E N M T K M G K A K I T D A K G A D Y T K V T F K P D Y A K F G M T G M D D D F E A L V K R R V Y D L A G T A K V A V K L N G S R I P I R N F K M Y M E M Y T K A I R R E R G D M G P A G K N E I I T C S P D P R W E V G F A V S D G A F Q Q V S F V N S I A I T S G G T H V N Y I A D Q I C S K L A E Q V K K K N K N G A T L K P A Q I R N H I F I F V N A L I V N P A F T S Q T K E Q L T T K Q S Q F G S K C V L E E D F Y K K I L K T E V M T N I L H F A Q Q K A D Q M L K K T D G G R R S R M N N P K L T D A N K A G T K E G H H C T L I L T E G D S A K G L A M A G R A V V G P D L F G V F P L R G K L L N V R D A S F D Q I A K N Q E I Q N I K N F I G L Q H K K E Y T D T R G L R Y G H L M I T T D Q D H D G S H I K G L L I N F L Q A Q F P S L L K I P E F L I E F I T P I V K V W K G D P K N P T K Q R S F F T M P E Y E A W K E E H G H E R G W E H K Y Y K G L G T S T T E D A Q I Y F R D L D R H L K E F H T M Q D N E V E L I E L A F S K K K A D E R K G N V R Q F R P G T F L D H S V D K I T Y T D F I N K E L I L F S M A D N I R S I P S V V D G L K P G Q R K V L Y T C F R R N L K K D M K V V E L A G H V S G T T A Y Q H G E G S L Q Q T I V G L A Q T F V G S N N V N C L E P S G N F G S R L Q G G A D C A S A R Y I Y T R L W P F A R R V F H N H D D P L L T Y N E D D G A K I E Q E V Y V P V V P M I L I N G A D G I G T G W S S S T P N Y N P E D I V E N L K R M M D G E P L K P M Q P W F R G F T G E V T A V G Q D R F K F S G I I K E T G D K E V E I T E L P I R T W T Q D F K D K L E D I I K A E K T P S F I K D Y K D Y N T H T K V H F V I Q M D E K H M K T A I A E G L E E K F K L S K T M T T T N L V A F D P E R I T K Y A S V E D I M K E F Y A V R L K Y Y E R R K Q Y Q L S E M Q K E L D K L S N Q A R F V Q M I I D G K L V I S K K K K A V L V A E L K E K D F K P F P K V K E A V K A G E T E P V V E E E E D S E S G D T E V L S N S Y D Y L L G M P I W S L T Q E R V E K L R R Q I G D K E L E I D T L I K L S K E D I W K R D L E D F I N E W R F Q N D E E A R R Q R K V A N M G R R T S S K L M T T G R G G G A A A R K R K A A L G D D P D D E D F A A P K S K K S A A A K K T E S K G G G L L S F L G K S S A K P K P S P A D G G D S D D D F D M E I M P K K S R G A P K S E P K A D P K P K D E D E D I V M E D S D I E E I I P K K S R G S S K P S V K P E S E D G Q A K I A E A P K R G R A A A K P K P K P K S E D E E D E L D D D D F M E I T K A E A A K P S A Q P A R S G R K T T K Y A E L S D S D S D N G D D L L G D V S K M V K G I G S T N G A S T S D S R L L F S E R S R P G S S A G L K T T A S K A S K P S E F D A D E T D Y S K L V P S N T P R R S L Q V K P K D A K V S D D N E P E D D D D E P V K P A A K G K A A A K G K S T A A A A N Q L L Q R L V V G R R K M L P K P P P R L P C P L P Q R R T H R S N P R P R R P R R R S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 833 833 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157