Uniprot ID	Q9ZMV7
Uniprot Name	TOP1_HELPJ
Taxonomy ID	85963
Sequence	M K H L I I V E S P A K A K T I K N F L D K N Y E V V A S K G H V R D L S K F A L G I K I D E T G F T P N Y V V D K D H K E L V K Q I I E L S K K A S I T Y I A T D E D R E G E A I G Y H V A C L I G G K L E S Y P R I V F H E I T Q N A I L N V L K T P R K I D M F K V N A Q Q A R R L L D R I V G F K L S S L I A S K I T K G L S A G R V Q S A A L K L V I D R E K E I R P F K P L T Y F T L D A L F E P H L E A Q L I S Y K G N K L K A Q E L I D E K K A Q E I K N E L E K E S Y I I S S I I K K S K K S P T P P P F M T S T L Q Q S A S S L L G F S P T K T M S I A Q K L Y E G V A T P Q G V M G V I T Y M R T D S L N I A K E A L E E A R A K I L K D Y G K D Y L P P K A K V Y S S K N K N A Q E A H E A I R P T S I I L E P N A L K D Y L K P E E L K L Y T L I Y K R F L A S Q M Q D A L F E S Q S V V V A C E K G E F K A S G R K L L F D G H Y K I L G N D D K D K L L P N L K E N D P I K L E K L E S N A H V T E P P A R Y S E A S L I K V L E S L G I G R P S T Y A P T I S L L Q N R D Y I K V E K K Q I S A L E S A F K V I E I L E K H F E E I V D S K F S A S L E E E L D N I A Q N K A D Y Q Q V L K D F Y Y P F M D K I E A G K K N I I S Q K V H E K T G Q S C P K C G G E L V K K N S R Y G E F I A C N N Y P K C K Y I K Q T E N A N D E A K Q E L C E K C G G E M V Q K F S R N G A F L A C N N Y P E C K N T K S L K N T P N A K E T I E G V K C P E C G G D I A L K R S K K G S F Y G C N N Y P K C N F L S N H K P I N K R C E K C H Y L M S E R I Y R K K K A H E C I Q C K E R V F L E E D N G
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952};
Active site	ACT_SITE 297 297 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}.
Pfam	PF01131 PF01751 PF01396
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR013498 IPR005733 IPR028612 IPR006171 IPR034149