Title | Date | PubMed ID |
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. | 2017 Aug 11 | 28684414 |
Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production. | 2016 Aug 9 | 27426448 |
Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line. | 2016 | 26526982 |
Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1). | 2015 | 26587646 |
The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1). | 2015 Jul | 25482340 |
Determination of 17α-hydroxylase-C17,20-lyase (P45017α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds. | 2015 Mar | 25740437 |
Anticancer activity of a novel selective CYP17A1 inhibitor in preclinical models of castrate-resistant prostate cancer. | 2015 Jan | 25351916 |
Novel oxazolinyl derivatives of pregna-5,17(20)-diene as 17α-hydroxylase/17,20-lyase (CYP17A1) inhibitors. | 2014 Oct | 24971814 |
Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17. | 2014 Jan 14 | 24328388 |
Active site proton delivery and the lyase activity of human CYP17A1. | 2014 Jan 3 | 24299954 |