TitleDatePubMed ID
Taxadiene-5α-ol is a minor product of CYP725A4 when expressed in Escherichia coli.2018 May28876471
Heterologous expression and characterization of plant Taxadiene-5α-Hydroxylase (CYP725A4) in Escherichia coli.2017 Apr28109855
Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate.2017 Feb 1727794603
Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4.2016 May 2026930136
Mechanistic Insights into Taxadiene Epoxidation by Taxadiene-5α-Hydroxylase.2016 Feb 1926677870
CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane.2008 Mar 718167342
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.2004 Mar15123267
Taxol biosynthetic genes.2001 Sep11524108
Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells.2001 Jun 1511396929
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis.1996 Jun8807878