| Title | Date | PubMed ID |
|---|
| Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design. | 2015 Mar 26 | 25695670 |
| Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS. | 2015 Feb | 25156639 |
| Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718). | 2014 Dec 11 | 25363711 |
| 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors. | 2014 Dec 11 | 25411915 |
| Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position. | 2014 Jan 15 | 24360554 |
| BACE1 activity regulates cell surface contactin-2 levels. | 2014 Jan 9 | 24405708 |
| Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method. | 2014 | 25254246 |
| Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. | 2013 Nov | 23406323 |
| Discovery of pyrazole as C-terminus of selective BACE1 inhibitors. | 2013 Oct | 23988410 |
| Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides. | 2013 Oct 1 | 23981898 |