Title | Date | PubMed ID |
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain. | 2014 Dec | 25240855 |
LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens. | 2014 Sep 30 | 25271285 |
Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. | 2014 Nov 13 | 25408833 |
Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer. | 2013 Nov 22 | 24108127 |
Design and synthesis of potent Gram-negative specific LpxC inhibitors. | 2011 Feb 15 | 21273067 |
Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions. | 2010 Oct 29 | 20709752 |
Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity. | 2010 Mar 16 | 20136146 |
Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay. | 2010 Jan | 20019290 |
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. | 2009 Apr 14 | 19256534 |
DFT investigation on the mechanism of the deacetylation reaction catalyzed by LpxC. | 2008 Mar 20 | 18302359 |