TitleDatePubMed ID
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.2014 Dec25240855
LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens.2014 Sep 3025271285
Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.2014 Nov 1325408833
Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.2013 Nov 2224108127
Design and synthesis of potent Gram-negative specific LpxC inhibitors.2011 Feb 1521273067
Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.2010 Oct 2920709752
Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity.2010 Mar 1620136146
Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay.2010 Jan20019290
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.2009 Apr 1419256534
DFT investigation on the mechanism of the deacetylation reaction catalyzed by LpxC.2008 Mar 2018302359