TitleDatePubMed ID
Insight into the cellular involvement of the two reverse gyrases from the hyperthermophilic archaeon Sulfolobus solfataricus.2014 Sep 925200003
A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.2014 Jun 124775914
The reverse gyrase from Pyrobaculum calidifontis, a novel extremely thermophilic DNA topoisomerase endowed with DNA unwinding and annealing activities.2014 Feb 724347172
QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα.201424516330
Substrate-mediated proton relay mechanism for the religation reaction in topoisomerase II.201424047515
Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks.2013 May23161103
Effect of short peptides containing lysine and epsilon-aminocaproic acid on fibrinolytic activity of plasmin and topoisomerase II action on supercoiled DNA.2013 May-Jun23757933
Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis.2013 Apr 122998676
A cysteine-reactive alkyl hydroquinone modifies topoisomerase IIα, enhances DNA breakage, and induces apoptosis in cancer cells.2012 Nov 1923088786
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.2012 Nov23022727