TitleDatePubMed ID
Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.2017 Dec29127710
Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.2016 Apr27070550
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.2014 Aug24853758
Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani.201424901644
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling.2013 Aug 1623814051
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase.201323451087
Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.2012 Jan 222162199
Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.2011 Dec22050226
Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.2010 Sep20726720
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.2009 Dec 2519828449