Potassium
(right click,save link as to download,it is a temp file,please download as soon as possible, you can also use CTRL+S to save the whole html page)
Basic Info
| Common Name | Potassium(F10472) |
| 2D Structure | |
| FRCD ID | F10472 |
| CAS Number | 7440-09-7 |
| PubChem CID | 5462222 |
| Formula | K |
| IUPAC Name | potassium |
| InChI Key | ZLMJMSJWJFRBEC-UHFFFAOYSA-N |
| InChI | InChI=1S/K |
| Canonical SMILES | [K] |
| Isomeric SMILES | [K] |
| Wikipedia | Potassium |
| Synonyms |
Potassium
7440-09-7
Kalium
Potassium, metal
Potassium, (liquid alloy)
UNII-RWP5GA015D
RWP5GA015D
HSDB 698
EINECS 231-119-8
UN2257
|
| Classifies |
Food Additive
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Inorganic compounds |
| Superclass | Homogeneous metal compounds |
| Class | Homogeneous alkali metal compounds |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Homogeneous alkali metal compounds |
| Alternative Parents | |
| Molecular Framework | Not available |
| Substituents | Homogeneous alkali metal |
| Description | This compound belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 39.098 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Complexity | 0 |
| Monoisotopic Mass | 38.964 |
| Exact Mass | 38.964 |
| Formal Charge | 0 |
| Heavy Atom Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
ADMET
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9733 |
| Human Intestinal Absorption | HIA+ | 0.9838 |
| Caco-2 Permeability | Caco2+ | 0.7354 |
| P-glycoprotein Substrate | Non-substrate | 0.8810 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.9787 |
| Non-inhibitor | 0.9858 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.9133 |
| Distribution | ||
| Subcellular localization | Lysosome | 0.5856 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.8466 |
| CYP450 2D6 Substrate | Non-substrate | 0.8259 |
| CYP450 3A4 Substrate | Non-substrate | 0.8158 |
| CYP450 1A2 Inhibitor | Non-inhibitor | 0.8844 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.9377 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.9711 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.9570 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.9885 |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8820 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9547 |
| Non-inhibitor | 0.9746 | |
| AMES Toxicity | Non AMES toxic | 0.9633 |
| Carcinogens | Carcinogens | 0.6491 |
| Fish Toxicity | Low FHMT | 0.6181 |
| Tetrahymena Pyriformis Toxicity | Low TPT | 0.6631 |
| Honey Bee Toxicity | High HBT | 0.8278 |
| Biodegradation | Ready biodegradable | 0.7326 |
| Acute Oral Toxicity | III | 0.5846 |
| Carcinogenicity (Three-class) | Warning | 0.4769 |
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -1.0958 | LogS |
| Caco-2 Permeability | 1.6017 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.0135 | LD50, mol/kg |
| Fish Toxicity | 1.5413 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | -0.7156 | pIGC50, ug/L |
References
| Title | Journal | Date | Pubmed ID |
|---|---|---|---|
| Determination of macro, micro and trace elements in citrus fruits by inductively coupled plasma-optical emission spectrometry (ICP-OES), ICP-mass spectrometry and direct mercury analyzer. | J Sci Food Agric | 2018 Sep 27 | 30264403 |
| Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats. | Appl Physiol Nutr Metab | 2018 Sep | 29847737 |
| Identification of cisplatin sensitizers through high-throughput combinatorial screening. | Int J Oncol | 2018 Sep | 29956742 |
| Effect of Diafenthiuron exposure under short and long term experimentalconditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita. | Environ Toxicol Pharmacol | 2018 Sep | 29957367 |
| Effects of potassium fertilization on potato starch physicochemical properties. | Int J Biol Macromol | 2018 Oct 1 | 29791875 |
| The toxic effects of monosodium glutamate (MSG) - The involvement of nitric oxide, prostanoids and potassium channels in the reactivity of thoracic arteries in MSG-obese rats. | Toxicol Appl Pharmacol | 2018 Nov 15 | 30244120 |
| Functional analysis of a type 2C protein phosphatase gene from Ammopiptanthusmongolicus. | Gene | 2018 May 5 | 29427736 |
| Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial. | J Sci Food Agric | 2018 May 30 | 29851070 |
| Buchanania obovata: An Australian Indigenous food for diet diversification. | Nutr Diet | 2018 May 27 | 29806144 |
| Synergistic Effects of Nitrogen and Potassium on Quantitative Limitations toPhotosynthesis in Rice ( Oryza sativa L.). | J Agric Food Chem | 2018 May 23 | 29715025 |
| Growth performance, blood parameters, carcass characteristics and meat qualitytraits in Potchefstroom Koekoek chickens fed Lippia javanica leaf meal. | Trop Anim Health Prod | 2018 May 22 | 29789988 |
| New Amphiphilic Composite for Preparing Efficient Coated Potassium-Fertilizersfor Top-Dressing Fertilization of Annual Crops. | J Agric Food Chem | 2018 May 16 | 29677445 |
| Hydrolysers of modified mycotoxins in maize: α-Amylase and cellulase induce an underestimation of the total aflatoxin content. | Food Chem | 2018 May 15 | 29329875 |
| Effect of potassium sorbate (E-202) and the antifungal PgAFP protein on Aspergillus carbonarius growth and ochratoxin A production in raisin simulating media. | J Sci Food Agric | 2018 May 13 | 29756353 |
| Parallel Evaluation of Two Potassium Channel Blockers in Restoring Conduction in Mechanical Spinal Cord Injury in Rat. | J Neurotrauma | 2018 May 1 | 29228863 |
| Nutritional value and potential chemical food safety hazards of selected Polishsausages as influenced by their traditionality. | Meat Sci | 2018 May | 29367119 |
| Pyrolysis and co-composting of municipal organic waste in Bangladesh: Aquantitative estimate of recyclable nutrients, greenhouse gas emissions, andeconomic benefits. | Waste Manag | 2018 May | 29439929 |
| Phloem transport capacity of transgenic rice T1c-19 (Cry1C*) under severalpotassium fertilizer levels. | PLoS One | 2018 Mar 29 | 29596474 |
| Current Strategies for the Detoxification of Jatropha curcas Seed Cake: A Review. | J Agric Food Chem | 2018 Mar 21 | 29498277 |
| Stable and radioactive cesium: A review about distribution in the environment,uptake and translocation in plants, plant reactions and plants' potential forbioremediation. | Sci Total Environ | 2018 Mar 15 | 29122347 |
Targets
- General Function:
- Steroid hormone binding
- Specific Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
- Gene Name:
- ATP1A1
- Uniprot ID:
- P05023
- Molecular Weight:
- 112895.01 Da
References
- Silva E, Gomes P, Soares-da-Silva P: Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol. 2006;212(3):163-75. Epub 2007 Feb 28. [17334838 ]