Vanadyl sulfate
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Basic Info
| Common Name | Vanadyl sulfate(F02403) |
| 2D Structure | |
| Description | Vanadium is widely distributed in the earth's crust. It occurs naturally in the form of about 70 minerals, but does not occur as metallic vanadium. In its compounds, it forms different oxidation states, the most common being +3, +4, and +5. |
| FRCD ID | F02403 |
| CAS Number | 27774-13-6 |
| PubChem CID | 22590178 |
| Formula | H2O5SV |
| IUPAC Name | vanadium(2+);sulfate;hydrate |
| InChI Key | HQKXGNCOVAYRNP-UHFFFAOYSA-L |
| InChI | InChI=1S/H2O4S.H2O.V/c1-5(2,3)4;;/h(H2,1,2,3,4);1H2;/q;;+2/p-2 |
| Canonical SMILES | O.[O-]S(=O)(=O)[O-].[V+2] |
| Isomeric SMILES | O.[O-]S(=O)(=O)[O-].[V+2] |
| Classifies |
Predicted: Pesticide
|
| Update Date | Nov 13, 2018 16:49 |
Chemical Taxonomy
| Kingdom | Inorganic compounds |
| Superclass | Mixed metal/non-metal compounds |
| Class | Transition metal oxoanionic compounds |
| Subclass | Transition metal sulfates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Transition metal sulfates |
| Alternative Parents | |
| Molecular Framework | Not available |
| Substituents | Transition metal sulfate - Inorganic oxide - Inorganic salt |
| Description | This compound belongs to the class of inorganic compounds known as transition metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is a transition metal. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 165.013 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 0 |
| Complexity | 62.2 |
| Monoisotopic Mass | 164.906 |
| Exact Mass | 164.906 |
| Formal Charge | 0 |
| Heavy Atom Count | 7 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 3 |
References
| Title | Journal | Date | Pubmed ID |
|---|---|---|---|
| Isoflavones Production and Possible Mechanism of Their Exudation in <i>Genista tinctoria</i> L. Suspension Culture after Treatment with Vanadium Compounds. | Molecules | 2018 Jul 3 | 29970854 |
| Impact of soil pH and organic matter on the chemical bioavailability of vanadium species: The underlying basis for risk assessment. | Environ Pollut | 2016 Mar | 26807983 |
| Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. | Proc Natl Acad Sci U S A | 2005 Oct 18 | 16217019 |
| Vanadium. | J Toxicol Clin Toxicol | 1999 | 10382561 |
| An assessment of the genotoxicity of vanadium. | Toxicol Lett | 1990 Feb | 2309250 |
Targets
- General Function:
- Transporter activity
- Specific Function:
- May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
- Gene Name:
- FXYD2
- Uniprot ID:
- P54710
- Molecular Weight:
- 7283.265 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
- Gene Name:
- PTPRU
- Uniprot ID:
- Q92729
- Molecular Weight:
- 162422.095 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Gene Name:
- PTPRA
- Uniprot ID:
- P18433
- Molecular Weight:
- 90599.295 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).
- Gene Name:
- PTPN13
- Uniprot ID:
- Q12923
- Molecular Weight:
- 276903.22 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
- Gene Name:
- PTPN6
- Uniprot ID:
- P29350
- Molecular Weight:
- 67560.79 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
- Gene Name:
- PTPN7
- Uniprot ID:
- P35236
- Molecular Weight:
- 40528.965 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
- Gene Name:
- PTPN9
- Uniprot ID:
- P43378
- Molecular Weight:
- 68019.58 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Zinc ion binding
- Specific Function:
- Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
- Gene Name:
- PTPN1
- Uniprot ID:
- P18031
- Molecular Weight:
- 49966.44 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Sh3/sh2 adaptor activity
- Specific Function:
- Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
- Gene Name:
- PTPN11
- Uniprot ID:
- Q06124
- Molecular Weight:
- 68436.0 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Sh3 domain binding
- Specific Function:
- Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.
- Gene Name:
- PTPN12
- Uniprot ID:
- Q05209
- Molecular Weight:
- 88105.665 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Sodium:potassium-exchanging atpase activity
- Specific Function:
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.Involved in cell adhesion and establishing epithelial cell polarity.
- Gene Name:
- ATP1B1
- Uniprot ID:
- P05026
- Molecular Weight:
- 35061.07 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Sodium:potassium-exchanging atpase activity
- Specific Function:
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
- Gene Name:
- ATP1B2
- Uniprot ID:
- P14415
- Molecular Weight:
- 33366.925 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Steroid hormone binding
- Specific Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
- Gene Name:
- ATP1A1
- Uniprot ID:
- P05023
- Molecular Weight:
- 112895.01 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Steroid hormone binding
- Specific Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
- Gene Name:
- ATP1A2
- Uniprot ID:
- P50993
- Molecular Weight:
- 112264.385 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Steroid hormone binding
- Specific Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
- Gene Name:
- ATP1A3
- Uniprot ID:
- P13637
- Molecular Weight:
- 111747.51 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Sodium:potassium-exchanging atpase activity
- Specific Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
- Gene Name:
- ATP1A4
- Uniprot ID:
- Q13733
- Molecular Weight:
- 114165.44 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Sodium:potassium-exchanging atpase activity
- Specific Function:
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
- Gene Name:
- ATP1B3
- Uniprot ID:
- P54709
- Molecular Weight:
- 31512.34 Da
- Mechanism of Action:
- The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration.
References
- Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. [18319605 ]
- General Function:
- Protein tyrosine/serine/threonine phosphatase activity
- Specific Function:
- Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
- Gene Name:
- PTPMT1
- Uniprot ID:
- Q8WUK0
- Molecular Weight:
- 22843.38 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine/serine/threonine phosphatase activity
- Specific Function:
- Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
- Gene Name:
- PTP4A1
- Uniprot ID:
- Q93096
- Molecular Weight:
- 19814.93 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Prenylated protein tyrosine phosphatase activity
- Specific Function:
- Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
- Gene Name:
- PTP4A2
- Uniprot ID:
- Q12974
- Molecular Weight:
- 19127.05 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine/serine/threonine phosphatase activity
- Specific Function:
- Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
- Gene Name:
- PTP4A3
- Uniprot ID:
- O75365
- Molecular Weight:
- 19534.69 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
- Gene Name:
- PTPRF
- Uniprot ID:
- P10586
- Molecular Weight:
- 212877.35 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.
- Gene Name:
- PTPRH
- Uniprot ID:
- Q9HD43
- Molecular Weight:
- 122351.35 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- Gene Name:
- PTPRN2
- Uniprot ID:
- Q92932
- Molecular Weight:
- 111270.29 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Wnt-protein binding
- Specific Function:
- Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
- Gene Name:
- PTPRO
- Uniprot ID:
- Q16827
- Molecular Weight:
- 138342.845 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
- Gene Name:
- PTPRR
- Uniprot ID:
- Q15256
- Molecular Weight:
- 73833.73 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Interacts with LAR-interacting protein LIP.1.
- Gene Name:
- PTPRS
- Uniprot ID:
- Q13332
- Molecular Weight:
- 217039.825 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- May be involved in both signal transduction and cellular adhesion in the CNS.
- Gene Name:
- PTPRT
- Uniprot ID:
- O14522
- Molecular Weight:
- 162132.92 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
- Gene Name:
- PTPRB
- Uniprot ID:
- P23467
- Molecular Weight:
- 224299.74 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Gene Name:
- PTPRD
- Uniprot ID:
- P23468
- Molecular Weight:
- 214758.455 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
- Gene Name:
- PTPRE
- Uniprot ID:
- P23469
- Molecular Weight:
- 80641.165 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
- Gene Name:
- PTPRJ
- Uniprot ID:
- Q12913
- Molecular Weight:
- 145940.37 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Possesses tyrosine phosphatase activity.
- Gene Name:
- PTPRG
- Uniprot ID:
- P23470
- Molecular Weight:
- 162002.3 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
- Gene Name:
- PTPRK
- Uniprot ID:
- Q15262
- Molecular Weight:
- 162100.87 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
- Gene Name:
- PTPRM
- Uniprot ID:
- P28827
- Molecular Weight:
- 163681.285 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transmembrane receptor protein tyrosine phosphatase activity
- Specific Function:
- Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
- Gene Name:
- PTPRZ1
- Uniprot ID:
- P23471
- Molecular Weight:
- 254585.05 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Spectrin binding
- Specific Function:
- Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Seems to lack intrinsic enzyme activity (By similarity).
- Gene Name:
- PTPRN
- Uniprot ID:
- Q16849
- Molecular Weight:
- 105846.52 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Transcription cofactor activity
- Specific Function:
- Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
- Gene Name:
- PTPN14
- Uniprot ID:
- Q15678
- Molecular Weight:
- 135260.15 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Non-membrane spanning protein tyrosine phosphatase activity
- Specific Function:
- Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
- Gene Name:
- PTPN18
- Uniprot ID:
- Q99952
- Molecular Weight:
- 50481.995 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Syntaxin binding
- Specific Function:
- Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.
- Gene Name:
- PTPN2
- Uniprot ID:
- P17706
- Molecular Weight:
- 48472.94 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
- Gene Name:
- PTPN20
- Uniprot ID:
- Q4JDL3
- Molecular Weight:
- 48422.455 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Gene Name:
- PTPN21
- Uniprot ID:
- Q16825
- Molecular Weight:
- 133279.965 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Ubiquitin protein ligase binding
- Specific Function:
- Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).
- Gene Name:
- PTPN22
- Uniprot ID:
- Q9Y2R2
- Molecular Weight:
- 91703.92 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
- Gene Name:
- PTPN23
- Uniprot ID:
- Q9H3S7
- Molecular Weight:
- 178971.945 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Sodium channel regulator activity
- Specific Function:
- May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
- Gene Name:
- PTPN3
- Uniprot ID:
- P26045
- Molecular Weight:
- 103989.11 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Non-membrane spanning protein tyrosine phosphatase activity
- Specific Function:
- May act at junctions between the membrane and the cytoskeleton.
- Gene Name:
- PTPN4
- Uniprot ID:
- P29074
- Molecular Weight:
- 105910.315 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]
- General Function:
- Protein tyrosine phosphatase activity
- Specific Function:
- May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
- Gene Name:
- PTPN5
- Uniprot ID:
- P54829
- Molecular Weight:
- 63537.53 Da
- Mechanism of Action:
- Vanadium inhibits protein tyrosine phosphatases, producing insulin-like effects.
References
- Wang J, Yuen VG, McNeill JH: Effect of vanadium on insulin sensitivity and appetite. Metabolism. 2001 Jun;50(6):667-73. [11398143 ]